Sökning: "ancestral sequences"

Visar resultat 11 - 15 av 29 avhandlingar innehållade orden ancestral sequences.

  1. 11. Reconciling gene family evolution and species evolution

    Författare :Joel Sjöstrand; Jens Lagergren; Nicolas Lartillot; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Computational biology; Bioinformatics; Phylogenetics; Phylogenomics; Comparative genomics; Evolutionary biology; datalogi; Computer Science;

    Sammanfattning : Species evolution can often be adequately described with a phylogenetic tree. Interestingly, this is the case also for the evolution of homologous genes; a gene in an ancestral species may – through gene duplication, gene loss, lateral gene transfer (LGT), and speciation events – give rise to a gene family distributed across contemporaneous species. LÄS MER

  3. 12. Bioinformatic protein family characterisation

    Författare :Joel Hedlund; Bengt Persson; Jaap Heringa; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : Biological research is necessary; not only to further our understanding of the processes of life, but also to combat disease, hunger and environmental damage.Bioinformatics is the science of handling biological information. It entails integrating, structuring and analysing the ever-increasing amounts of available biological data. LÄS MER

  4. 13. Causes of Substitution Frequency Variation in Pathogenic Bacteria

    Författare :Wagied Davids; Siv Andersson; Otto Berg; Bengt Persson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Comparative genomics; Molecular evolution; Bioinformatics; Human pathogens; Rickettsia; Helicobacter pylori; Biologi; Biology; Biologi;

    Sammanfattning : Estimating substitution frequencies at sites that influence (Ka) and do not influence (Ks) the amino acid sequence is important for understanding the dynamics of molecular sequence evolution and the selective pressures that have shaped genetic variation. The aim of this work was to gain a deeper understanding of the driving forces of substitution frequency variation in human pathogens. LÄS MER

  5. 14. Alpha-actinin - an amazing journey through time and species

    Författare :Barbara Addario; Lars Backman; Yari Ylänne; Umeå universitet; []
    Nyckelord :;

    Sammanfattning : In eukaryotes, the actin cytoskeleton plays an important role in a large variety of cellular events. Its reorganization is regulated by a plethora of actin-modulating proteins, such as α-actinin. α-actinin is a ubiquitous actin-binding protein that belongs to the spectrin superfamily. LÄS MER

  7. 15. Evolution of MHC Genes and MHC Gene Expression

    Författare :Karin Berggren Bremdal; Hans Ellegren; Jennifer Seddon; Philip Hedrick; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; major histocompatibilty complex; dog leukocyte antigen; balancing selection; linkage disequilibrium; promoter; diabetes mellitus; Canis familiaris; Canis lupus; Erinaceus europaeus; Erinaceus concolor; Genetics; Genetik; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : Polymorphism in coding regions and regions controlling gene expression is the major determinant of adaptive differences in natural populations. Genes of the major histocompatibility complex (MHC) possess a high level of genetic variation, which is maintained by selection over long coalescence times. LÄS MER