Sökning: "analytical tools"

Visar resultat 1 - 5 av 514 avhandlingar innehållade orden analytical tools.

  1. 1. Integrated Micro-Analytical Tools for Life Science

    Författare :Sara Bergström; Karin Markides; Marit Andersson; Marja-Liisa Reikkola; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Microdialysis; Multidimensional separation; Liquid chromatography LC ; Capillary electrophoresis CE ; Electrospray ionisation ESI ; Mass spectrometry MS ; Microchip device; Free drug concentration; Screening of microdialysates; Pattern recognition; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Advances in life science require knowledge of active molecules in complex biological systems. These molecules are often only present for a certain time and at limited concentrations. LÄS MER

  2. 2. Analytical Quality by Design Method Development for Vaccine Characterization

    Författare :Lars Geurink; Catharina Sänger van de Griend; Mikael Hedeland; Martijn Schenning; Iulia Oita; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; viral vaccines; adenovirus; influenza; polio; COVID; corona; capillary electrophoresis; analytical quality by design; analytical method development; CGE; icIEF; CZE; crude cell suspension analysis; in-process sample analysis; quality control testing; biopharmaceutical characterization; Analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : Vaccines that are safe, efficacious, and can be rapidly developed are needed to prevent and to react to emerging global infectious disease threats such as influenza, Polio, and Coronavirus diseases. Fast and reliable analytical methods are required without delay to support vaccine process and product development, characterization, and quality control testing. LÄS MER

  3. 3. New Tools for Trapping and Separation in Gas Chromatography and Dielectrophoresis : Improved Performance by Aid of Computer Simulation

    Författare :Fredrik Aldaeus; Anders Colmsjö; Marja-Liisa Riekkola; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; gas chromatography; dielectrophoresis; computer simulation; finite element method; trapping; separation; lab-on-a-chip; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Computer simulations can be useful aids for both developing new analytical methods and enhancing the performance of existing techniques. This thesis is based on studies in which computer simulations were key elements in the development of several new tools for use in gas chromatography and dielectrophoresis. LÄS MER

  4. 4. Determination of biomarkers for lipid peroxidation and oxidative stress : Development of analytical techniques and methods

    Författare :Kristina Claeson Bohnstedt; Bo Karlberg; Niels Heegaard; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; capillary electrophoresis; mass spectrometry; electrospray; porous graphitic carbon; oxidative stress; lipid peroxidation; biomarker; malondialdehyde; hydroxynonenal; isoprostane; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Oxidative stress can be defined as a state of disturbance in the pro-oxidant/antioxidant balance in favour of the former, leading to potential damage. Processes associated with oxidative stress involve reactive oxygen species and radicals and can result in elevated levels of oxidatively modified or toxic molecules that can cause cellular malfunction, and even cell death. LÄS MER

  5. 5. Process analytical methods for monitoring of the film coating on pharmaceutical pellets and tablets using NIR spectrometry and image analysis

    Författare :Martin Andersson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PLS; PCA; PAC; NIR; chemometrics; moving samples; information depth; release rate; image analysis; near infrared; process analytical chemistry; thickness; coating; film; tablets; Pellets; granules; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Pharmaceutical tablets and pellets are often covered with a coating. There is a need for methods that enable monitoring of the growth of such films during processing. Such analyses can be performed using process analytical chemical methods based on near infrared (NIR) diffuse reflectance spectrometry. It provides with analyses that take only ca. LÄS MER