Sökning: "analytical approach"

Visar resultat 21 - 25 av 1028 avhandlingar innehållade orden analytical approach.

1. 21. Processing and analysis of NMR data : Impurity determination and metabolic profiling

   Författare :Jenny Forshed; Sven P. Jacobsson; Jules L. Griffin; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; quantitative nuclear magnetic resonance spectrometry; qNMR; multivariate analysis; peak alignment; data fusion; Analytical chemistry; Analytisk kemi;

   Sammanfattning : This thesis describes the use of nuclear magnetic resonance (NMR) spectrometry as an analytical tool. The theory of NMR spectroscopy in general and quantitative NMR spectrometry (qNMR) in particular is described and the instrumental properties and parameter setups for qNMR measurements are discussed. LÄS MER

3. 22. Physicochemical and Biopharmaceutical Characterisation of Small Drug Molecules by Capillary Electrophoresis

   Författare :Eivor Örnskov; Staffan Folestad; Karin E. Markides; Morteza Khaledi; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; capillary electrophoresis CE ; micellar electrokinetic chromatography MEKC ; drug; liposome; microemulsion; coating; pKa; lipophilicity; multivariate analysis; molecular descriptor; hierarchical analysis; passiv absorption; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : Capillary Electrophoresis (CE) was explored as a means for physicochemical and biopharmaceutical characterisation of small drug molecules. Special attention was paid to the characterisation of acid-base and lipophilic properties of drug compounds by analysing their migration behaviour in different CE systems. LÄS MER

4. 23. Electrospray Ionization Mass Spectrometry for Determination of Noncovalent Interactions in Drug Discovery

   Författare :Kurt Benkestock; Johan Roeraade; Renato Zenobi; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; electrospray ionization; drug discovery; noncovalent interaction; complexes; human serum albumin HSA ; fatty acid binding protein FABP ; ribonuclease; ligand screening; Analytical chemistry; Analytisk kemi;

   Sammanfattning : Noncovalent interactions are involved in many biological processes in which biomolecules bind specifically and reversibly to a partner. Often, proteins do not have a biological activity without the presence of a partner, a ligand. LÄS MER

5. 24. Mass Spectrometry Strategies for Characterization of Contact Allergens and their Protein Conjugates in Vitro and in Vivo

   Författare :Lorena Ndreu; Isabella Karlsson; Margareta Törnqvist; Ulrika Nilsson; Maja Aleksic; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; Skin allergy; Protein Adducts; In vitro methods; Bioanalysis; Analytical Chemistry; analytisk kemi;

   Sammanfattning : Humans are daily exposed to chemicals from various sources, including cosmetics, jewelry, clothes, and hair dyes, which can result in the occurrence of contact allergy and subsequent allergic contact dermatitis (ACD), a type IV delayed hypersensitivity reaction. ACD is characterized by inflammation and eczema at the site of exposure, and no definitive cure for this condition has been identified to date, with only symptomatic treatment options involving corticosteroids being available. LÄS MER

7. 25. Amperometric Carbon Paste Biosensors Based on Horseradish Peroxidase and Oxidases

   Författare :Vijayakumar Rajendran; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; on-line monitoring; l-lactate; glucose; ethanol; Biosensor; Carbon paste; Analytisk kemi;

   Sammanfattning : Amperometric carbon paste peroxide sensors based on horseradish peroxidase (HRP) were developed. In the first approach, HRP was chemically modified with polyethylene glycol to improve the stability of the enzyme in the organic paste matrix and compared with native HRP electrode. LÄS MER