Sökning: "amyloid-beta precursor protein"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden amyloid-beta precursor protein.

1. 1. Physiological roles of amyloid precursor protein in vivo - zebrafish as a model

   Författare :Jasmine Chebli; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid-beta precursor protein; amyloid precursor protein-b; zebrafish; physiological functions; development; trigeminal ganglia; ependyma; cilia; proteomics; translational adaptation;

   Sammanfattning : Amyloid-beta precursor protein (APP) is an evolutionarily conserved transmembrane protein expressed in many different tissues. APP belongs to a gene family consisting of two other APP-like proteins (APLP1 and APLP2). LÄS MER

3. 2. Characterization of the novel “Uppsala mutation” causing a familial form of early onset Alzheimer’s disease

   Författare :María Pagnon de la Vega; Martin Ingelsson; Dag Sehlin; Vilmantas Giedraitis; Gunnar Gouras; Uppsala universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; neurodegeneration; amyloid precursor protein; APP processing; amyloid beta; transgenic mouse model;

   Sammanfattning : The Alzheimer’s disease (AD) brain displays extracellular plaques of amyloid-β (Aβ), neurofibrillary tangles of tau and neuronal loss. The 40-42 amino acid Aβ peptide is formed from the amyloid precursor protein (APP) by β-secretase and γ-secretase, while α-secretase prevents Aβ generation. LÄS MER

4. 3. Interplay between autophagy and amyloid beta metabolism in Alzheimer’s disease

   Författare :Richeng Jiang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by two pathological hallmarks: extracellular amyloid-beta peptide (Aβ) plaque depositions and neurofibrillary tangles (NFTs) composed of intracellular hyperphosphorylated tau aggregations. A cellular degradation system, autophagy is additionally dysfunctional in AD and plays a key role in Aβ and tau metabolisms. LÄS MER

5. 4. Aβ Conformation Dependent Antibodies and Alzheimer's Disease

   Författare :Dag Sehlin; Lars Lannfelt; Frida Ekholm Pettersson; David Teplow; Uppsala universitet; []
   Nyckelord :Alzheimer s disease; amyloid-beta; protofibrils; conformation; monoclonal antibody; ELISA; MEDICINE; MEDICIN; Geriatrics; Geriatrik;

   Sammanfattning : Soluble intermediates of the amyloid-β (Aβ) aggregation process are suggested to play a central role in the pathogenesis of Alzheimer’s disease (AD) by causing synaptic dysfunction and neuronal loss. In this thesis, soluble Aβ aggregates have been studied with a particular focus on the Aβ protofibril, which has served as the antigen for developing conformation dependent monoclonal antibodies. LÄS MER

7. 5. Physiological role of amyloid precursor protein during neural development

   Författare :Rakesh Kumar Banote; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid precursor protein; Zebrafish; Spinal cord; Motor neurons; Hindbrain; Mauthner cell; Development; Proteomics;

   Sammanfattning : Amyloid precursor protein (APP) is a type-one membrane-spanning protein with a large extracellular N-terminal domain and a small intracellular C-terminal domain. APP first gained interest due to its involvement in the pathogenesis of Alzheimer’s disease (AD). LÄS MER