Sökning: "amyloid imaging"

Visar resultat 21 - 25 av 59 avhandlingar innehållade orden amyloid imaging.

  1. 21. The heart in hereditary transthyretin amyloidosis : clinical studies on the impact of amyloid fibril composition

    Författare :Björn Pilebro; Ole Suhr; Henning Mölgaard; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloidosis; Transthyretin; Cardiomyopathy; Echocardiography; Scintigraphy; Positron emission tomography; cardiovascular disease; hjärt- och kärlforskning; kardiologi; Cardiology; Clinical Physiology; klinisk fysiologi;

    Sammanfattning : Background Hereditary transthyretin amyloid (ATTRm) amyloidosis is a systemic disease mainly affecting the peripheral nervous system and the heart. The disease is inherited in an autosomal dominant manner with a varying penetrance. It is caused by mutations in the transthyretin (TTR) gene. Today more than 100 disease causing mutations are known. LÄS MER

  3. 22. On the nature of mixed neurodegenerative amyloidopathies

    Författare :Nadja Gustavsson; NanoLund: Centre for Nanoscience; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin och hälsovetenskap; Parkinson s disease PD ; Alzheimers disease AD ; Amyloidosis; Alpha synuclein; Amyloid beta;

    Sammanfattning : Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases in the world. It has been possible to identify common denominators for AD and PD, including aggregation of the amyloid proteins amyloid-beta (Aβ) and alpha-synuclein (α-syn). LÄS MER

  4. 23. Interplay between autophagy and amyloid beta metabolism in Alzheimer’s disease

    Författare :Richeng Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by two pathological hallmarks: extracellular amyloid-beta peptide (Aβ) plaque depositions and neurofibrillary tangles (NFTs) composed of intracellular hyperphosphorylated tau aggregations. A cellular degradation system, autophagy is additionally dysfunctional in AD and plays a key role in Aβ and tau metabolisms. LÄS MER

  5. 24. Synthesis and characterization of fluorescent stilbene-based probes targeting amyloid fibrils

    Författare :Jun Zhang; Peter Konradsson; Per Hammarström; Xiongyu Wu; Lin Li; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Alzheimer’s disease (AD) is characterized by two main protein aggregate hallmarks in the brain: extracellular deposition of the amyloid-β (Aβ) in senile plaques and intracellular neurofibrillary tangles (NFTs) consisting of hyperphosphorylated tau protein. The past decade has seen great progress in the development of imaging probes for the non-invasive detection of Aβ and tau aggregates. LÄS MER

  7. 25. Molecular imaging of tau in the pathological cascade of Alzheimer’s disease

    Författare :Konstantinos Chiotis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The pathology of Alzheimer’s disease (AD) is characterised by the misfolding and aggregation of amyloid-β (Aβ) into extracellular plaques and aggregation of tau into intracellular neurofibrillary tangles. Recent advances in molecular imaging have allowed the development of positron emission tomography (PET) tracers for the in vivo detection of Aβ plaques while current efforts focus on the evaluation of recently proposed tracers targeting tau pathology. LÄS MER