Sökning: "amyloid fibril formation"

Visar resultat 21 - 25 av 66 avhandlingar innehållade orden amyloid fibril formation.

  1. 21. Molecular basis and pharmacological implications of Alzheimer amyloid ß-peptide fibril formation

    Författare :Lars Tjernberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; amyloid; fibrils; inhibitor; protease resistance; electron microscopy; fluorescence correlation spectroscopy.;

    Sammanfattning : Alzheimer's disease is a progressive neurodegenerative disease, mostly affecting elderly. The invariable deposition of protease-resistant fibrils of Alzheimer amyloid ß-peptide (Aß) in the parenchyma and blood vessels of the brain is a central event. LÄS MER

  3. 22. Islet amyloid polypeptide (IAPP) : Mechanisms of Amyloidogenesis in the Pancreatic Islets and Potential Roles in Diabetes Mellitus

    Författare :Zhi Ma; Arne Andersson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Islet amyloid is the most common characteristic feature of the islets in type 2 diabetes, being found in up to 90% of diabetic patients at post-mortem. lt has as its unique component the islet beta-cell peptide islet amyloid polypeptide (IAPP), which is eo-secreted with insulin. LÄS MER

  4. 23. Protein misfolding and amyloid formation : strategies for prevention

    Författare :Charlotte Nerelius; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Most proteins need to adopt a three-dimensional structure in order to function properly. Misfolding, or inability of proteins to fold, is associated with a number of diseases. In a subset of these disorders, the misfolded protein or peptide selfassembles into stable, β-sheet rich structures known as amyloid fibrils. LÄS MER

  5. 24. Amyloid β peptide: from monomer solubility to fibril structure

    Författare :Veronica Lattanzi; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer´s disease; Aβ solubility; small angle scattering; number of filaments; Aβ40; Aβ42 and Aβ42 S26Q ; fibril structure;

    Sammanfattning : Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. LÄS MER

  7. 25. Studies on Pathogenesis of Experimental AA Amyloidosis : Effects of Amyloid Enhancing Factor and Amyloid-Like Fibrils in Rapid Amyloid Induction

    Författare :Katarzyna Lundmark; D. Carleton Gajdusek; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Amyloidosis is a group of diseases, caused by an extracellular deposition of a characteristic proteinaceous material, amyloid, in various organs. Fibril formation occurs in all of amyloid related diseases, making it a crucial mechanism to understand. LÄS MER