Sökning: "amyloid fibril formation"

Visar resultat 16 - 20 av 66 avhandlingar innehållade orden amyloid fibril formation.

1. 16. Self-assembly of amyloid-β peptides in the presence of metal ions and interacting molecules – a detour of amyloid building blocks

   Författare :Cecilia Mörman; Astrid Gräslund; Daniel Otzen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biophysics; Alzheimer’s disease; protein aggregation; amyloid formation; amyloid-β peptide; aggregation kinetics; interactions; metal ions; designed peptide constructs; Tau protein; NMR; circular dichroism; fluorescence spectroscopy; Biophysics; biofysik;

   Sammanfattning : Misfolding of proteins into amyloid structures is implicated as a pathological feature in several neurodegenerative diseases and the molecular causes are still unclear. One typical characteristic of Alzheimer’s disease is self-assembly and accumulation of soluble amyloid-β (Aβ) peptides into insoluble fibrils and plaques. LÄS MER

3. 17. Conjugated Polymers, Amyloid Detection and Assembly of Biomolecular Nanowires

   Författare :Anna Herland; Olle Inganäs; Samuel I. Stupp; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Conjugated Polymers; Amyloid Fibrils; Nanowires; Self-Assembly; Sensor; Amyloid Detection; Physics; Fysik;

   Sammanfattning : The research field of conjugated polymers has grown due to the optical and electronic properties of the material, useful in applications such as solar cells and printed electronics, but also in biosensors and for interactions with biomolecules. In this thesis conjugated polymers have been used in two related topics; to detect conformational changes in proteins and to assemble the polymers with biomolecules into nanowires. LÄS MER

4. 18. Palmitoylation and amyloid fibril formation of lung surfactant protein C

   Författare :Magnus Gustafsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Lung surfactant is a mixture of lipids and a few proteins, of which surfactant proteins (SP)-B and SP-C are lipophilic. Surfactant is essential for the reduction of surface tension at the alveolar air/liquid interface. LÄS MER

5. 19. Co-assembly of proteins and lipids : From lipodiscs to amyloid aggregates

   Författare :Rebecca Frankel Willén; NanoLund: Centre for Nanoscience; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amyloid; Aβ42; apolipoprotein A-1; aggregation; high-density lipoprotein; DNAJB6; Alzheimer s disease; protein-lipid interactions;

   Sammanfattning : Assemblies of different molecules is a prevalent phenomenon in nature, and crucial in biological life. Most of the biological assemblies are co-assembledcomposites, made up from several different components, either of thesame biomolecular type or a combination of different ones. LÄS MER

7. 20. Deposition and Resolution of AA Amyloid

   Författare :Sofia N. Nyström; Gunilla T Westermark; Christoph Röcken; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AA-amyloid; autophagy; resolution; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi;

   Sammanfattning : Amyloidosis is a group of protein misfolding diseases characterized by extracellulardeposition of fibrillar protein aggregates. Today more than 25 different human amyloidogenicproteins have been identified, causing a variety of pathological conditions that includeAlzheimer’s disease, type 2 diabetes and prion diseases. LÄS MER