Sökning: "amyloid fibril formation"

Visar resultat 11 - 15 av 66 avhandlingar innehållade orden amyloid fibril formation.

  1. 11. Cellular Uptake of Amyloid Forming Proteins Related to Neurodegenerative Disease

    Författare :Emelie Vilhelmsson Wesén; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aβ 1-40 ; flow cytometry; confocal microscopy; SH-SY5Y; fluorescence; Aβ 1-42 ; Alzheimer’s disease; amyloid fibril; α-synuclein; amyloid-β;

    Sammanfattning : Aggregation and deposition of disease-associated protein is a pathological hallmark of several human disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). These diseases are characterized by the formation of amyloid-β (Aβ) and α-synuclein (α-syn) amyloid fibrils, in extracellular and intracellular locations, respectively. LÄS MER

  3. 12. Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation

    Författare :Ola Philipson; Lars Nilsson; Lars Lannfelt; Fred van Leuven; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Amyloid; Amyloid-β; intraneuronal; transgenic mice; immunohistochemistry; ELISA; Public health medicine research areas; Folkhälsomedicinska forskningsområden; Geriatrics; Geriatrik;

    Sammanfattning : The Arctic mutation in the Amyloid-β (Aβ) domain of the Amyloid-β precursor protein (APP) causes Alzheimer’s disease (AD) and confers unique biochemical characteristics to Aβ peptides. The aims of this thesis were to evaluate a transgenic model with the Arctic mutation, and to use it to gain new insights into the mechanisms of early (pre-plaque) and late-stage Aβ pathogenesis in AD. LÄS MER

  4. 13. Islet Amyloid Polypeptide: Interaction with Amyloid Beta, Alpha-Synuclein and BRICHOS

    Författare :Ye Wang; Gunilla Westermark; Ludmilla Morozova-Roche; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; Abeta; alpha-synuclein; Bri2 BRICHOS; luminescent conjugated oligothiophenes; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning :  Amyloid, the congophilic deposits of misfolded protein, are pathological hallmarks of many common diseases, among others, Alzheimer’s disease (AD), Parkinson’s disease (PD), and type 2 diabetes (T2D). Amyloid beta (Aβ) forms senile plaques in AD, alpha-synuclein (aSyn) forms Lewy bodies and Lewy neurites in PD, islet amyloid polypeptide (IAPP) forms islet amyloid in T2D. LÄS MER

  5. 14. Development of the Amyloid Fibril Characterisation Toolbox - New use for old dyes

    Författare :David Lindberg; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Amyloid-β; Thioflavin-T; Fluorescence spectroscopy; YOYO-1; Amyloid fibrils; Linear dichroism; Alzheimer’s disease;

    Sammanfattning : Amyloid fibrils are self-assembled protein homopolymers that playcentral roles in the pathology of several human diseases, most notably in progressiveneurodegenerative diseases such as Alzheimer’s disease (AD). In AD, fibrils areformed by the amyloid-β (Aβ) peptide, an enzymatic cleavage product that is naturallyproduced in human brain tissue. LÄS MER

  7. 15. Mechanisms involved in amyloid induced cytotoxicity

    Författare :Johan Östman; Lars Lannfelt; Umeå universitet; []
    Nyckelord :amyloid; transthyretin; cytotoxicity; apoptosis; caspases; aggregation; molekylärbiologi; Molecular Biology;

    Sammanfattning : Amyloidoses comprise a group of diseases where normal or mutated protein precipitates into amyloid fibrils. The deposition of fibrils causes dysfunction of organs and toxicity to nervous tissue. Up to date, 24 different proteins and peptides are known to be able to form amyloid fibrils. LÄS MER