Sökning: "amyloid beta peptide"

Visar resultat 6 - 10 av 70 avhandlingar innehållade orden amyloid beta peptide.

1. 6. Kinetic stabilization of transthyretin and its role as an inhibitor of Aβ amyloid formation

   Författare :Lina Nilsson; Anders Olofsson; Elisabeth Sauer-Eriksson; Gunilla Westermark; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amyloid; transthyretin; amyloid beta; kinetic stabilizer; biokemi; Biochemistry;

   Sammanfattning : Amyloid formation occurs when normally soluble proteins and peptides misfold and aggregate into intractable threadlike structures called fibrils. There are currently more than 30 proteins associated with this aberrant structure, including the Aβ peptide in Alzheimer’s disease (AD) and transthyretin (TTR) in TTR amyloidosis. LÄS MER

3. 7. Revealing the complex nature of amyloid beta and its relation to dementia

   Författare :Eleni Gkanatsiou; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s Disease; Amyloid beta; Mass spectrometry; Cerebral amyloid angiopathy; Down Syndrome; Pathological ageing; Dementia with Lewy bodies; Parkinson s disease dementia; dementia;

   Sammanfattning : Alzheimer disease (AD) is the most common type of dementia and characterized by the accumulation of amyloid plaques in the extracellular space of the brain parenchyma. Amyloid plaques consist of amyloid beta peptides (Aβ). Amyloid pathology can also be involved in other types of dementia, either as a driving force or as a coexisting pathology. LÄS MER

4. 8. Understanding secondary nucleation of the amyloid β peptide

   Författare :Dev Thacker; NanoLund: Centre for Nanoscience; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease AD ; A beta 1-42; Amyloid aggregation; secondary nucleation;

   Sammanfattning : Alzheimer’s Disease (AD) is a devastating neurodegenerative disease associated with massive neuronal cell death during its pathology. The involvement of the amyloid β 42 (Aβ42) peptideand its role in neurotoxicity is now well established. LÄS MER

5. 9. Mechanisms involved in amyloid induced cytotoxicity

   Författare :Johan Östman; Lars Lannfelt; Umeå universitet; []
   Nyckelord :amyloid; transthyretin; cytotoxicity; apoptosis; caspases; aggregation; molekylärbiologi; Molecular Biology;

   Sammanfattning : Amyloidoses comprise a group of diseases where normal or mutated protein precipitates into amyloid fibrils. The deposition of fibrils causes dysfunction of organs and toxicity to nervous tissue. Up to date, 24 different proteins and peptides are known to be able to form amyloid fibrils. LÄS MER

7. 10. Beta-amyloid, tau-protein and cystatin C in the pathophysiology of Alzheimer´s disease

   Författare :Maj-Linda Selenica; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; neurophysiology; Neurology; Medicine human and vertebrates ; Medicin människa och djur ; Clinical chemistry; Klinisk kemi; Kinase inhibitors; Tau protein; Cystatin C; Glycogen Synthase Kinase; Alzheimers Disease; Amyloid beta;

   Sammanfattning : Alzheimer´s Disease (AD) is a progressive neurodegenerative dementia characterized by the extracellular accumulation of the beta-amyloid (Ab) peptide into plaques and intracellular phosphorylation and accumulation of tau protein into neurofibrillary tangles (NFT). Inflammation due to astrocytic and microglial activation is one of the ongoing processes in the disease giving rise to cytokine production and oxidative stress. LÄS MER