Sökning: "amorphous degradable copolymer"

Hittade 4 avhandlingar innehållade orden amorphous degradable copolymer.

  1. 1. The role of computer-aided design and surface chemistry on Cell-scaffold interactions

    Författare :Sun Yang; Anna Finne-Wistrand; Ann-Christine Albertsson; Jinshan Pan; My Hedhammar; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amorphous degradable copolymer; aliphatic polyester; 3D fiber deposition; computer-aided design; Tween 80; BMSC; hOB; porous scaffolds;

    Sammanfattning : Cell interactions and cell response to three dimensional scaffolds based on poly(L-lactide-co-1,5-dioxepan-2-one) [poly(LLA-co-DXO)] and poly(L-lactide-co-e-caprolactone) [poly(LLA-co-CL)] wereimprovedstudiedby increasing surface hydrophilicity and by using computer-aided scaffold design. Different amounts of Tween 80 (3, 10, 20 wt%) were mixed with the copolymer and it was found that the water contact angle decreased significantly with the amount of Tween 80. LÄS MER

  3. 2. Macromolecular synthesis of functional degradable aliphatic polyesters and porous scaffold design

    Författare :Sofia Målberg; Ann-Christine Albertsson; Anders Södergård; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; functional polyesters; condensation polymerization; L-lactide; ε-caprolactone; triblock copolymer; mechanical properties; porous scaffolds; tissue engineering; ring-opening polymerization; Bi III acetate; creatinine; stannous 2-ethylhexanoate; enzyme; degradation products; Polymer chemistry; Polymerkemi;

    Sammanfattning : There is an increasing demand for new materials in biomedical applications with material properties that are highly specific for each application area. The search for new materials requires the creation of materials with suitable mechanical properties, functionalities, three-dimensional structures and a controlled degradation profile. LÄS MER

  4. 3. Synthesis of functional degradable polymers by radical ring-opening polymerization

    Författare :Jenny Undin; Ann-Christine Albertsson; Mats Johansson; Monica Ek; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; tissue engineering; ring-opening polymerization; 2; 2´-azoisobutyronitrile; cyclic ketene acetals; 2-methylene- 1; 3; 6-trioxocane; 2-methylene- 1; 3-dioxepane; vinyl acetate; coopolymerization;

    Sammanfattning : The increased demand for understanding cell-material interactions and subsequently create personalized implants for tissue engineering has resulted in an increased interest in developing new monomers with functional groups. The focus of the work presented in this thesis has been on the synthesis of functional monomers and the polymerization of these into functional amorphous aliphatic polyesters. LÄS MER

  5. 4. Engineering and Functionalization of Degradable Scaffolds for Medical Implant Applications

    Författare :Yang Sun; Anna Finne-Wistrand; Ann-Christine Albertsson; Minna Kellomäki; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Tissue engineering; nanodiamond; scaffold; bioreactor; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Sammanfattning : The treatment of bone defects is facing the situation of lacking donations for autotransplantation. As a valid approach, scaffold-based tissue engineering combines the construction of well-defined porous scaffolds with advanced cell culturing technology to guide tissue regeneration. LÄS MER