Sökning: "amino acid"

Visar resultat 11 - 15 av 1147 avhandlingar innehållade orden amino acid.

1. 11. The Biological Importance of the Amino Acid Transporter SLC38A10 : Characterization of a Knockout Mouse

   Författare :Frida A. Lindberg; Robert Fredriksson; Erika Roman; Karin Nordenankar; Vootele Vöikar; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Solute carrier; SLC; SNAT10; SLC38A10; phenotyping; behavior; amino acids; knockout mouse model; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : The biggest group of transporters, the solute carriers (SLCs), has more than 400 members, and about 30% of these are still orphan. In order to decipher their biological function and possible role in disease, there is a need for characterization of these. LÄS MER

3. 12. Exploring amino-acid radicals and quinone redox chemistry in model proteins

   Författare :Kristina Westerlund; Cecilia Tommos; Astrid Gräslund; Sara Linse; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amino-acid radicals; quinone redox chemistry; model proteins; protein redesign; electrochemistry; Biochemistry; Biokemi; biokemi; Biochemistry;

   Sammanfattning : Amino-acid radical enzymes have been studied extensively for 30 years but the experimental barriers to determine the thermodynamic properties of their key radical cofactors are so challenging that only a handful of reports exist in the literature. This is a major drawback when trying to understand the long-range radical transfer and/or catalytic mechanisms of this important family of enzymes. LÄS MER

4. 13. Characterization of Amino Acid tRNA Ligases using the Analytical Ultracentrifuge

   Författare :Lars Lundvik; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amino acid tRNA ligase; analytical ultracentrifugation;

   Sammanfattning : ABSTRACT. Quaternary structures of amino acid tRNA ligases/synthetases (aaRS) in the native as well as in denatured forms were examined by molecular weight determinations (paper I-IV). Analytical ultracentrifugation, gel electrophoresis, gel chromatography were used in these investigations. LÄS MER

5. 14. Group (IV) Metal-Catalyzed Direct Amidation : Synthesis and Mechanistic Considerations

   Författare :Helena Lundberg; Adolfsson Hans; Tom Sheppard; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; catalysis; amide; carboxylic acid; amino acid; titanium; zirconium; hafnium; organisk kemi; Organic Chemistry;

   Sammanfattning : The amide unit constitutes the backbone of proteins, and it is present in a large number of pharmaceutically active molecules, polymeric materials such as nylon and Kevlar, as well as in food additives like aspartame. Amides are produced in enormous amounts every year, thus, environmentally friendly and selective methods for their formation are of great importance. LÄS MER

7. 15. Characterization of a new amino acid transport system in human epidermal Langerhans cells

   Författare :Niels Bendsöe; Lund Dermatologi och venereologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amino acid transport; energy charge; epidermis; glycolysis; lactate; Langerhans cells; L-dopa; mitochondria; omeprazole; Dermatology; venereology; Dermatologi; venereologi;

   Sammanfattning : Based on the discovery of a new amino acid transport system in Langerhans cells (LC), various aspects concerning the L-dopa uptake mechanism into human epidermal LC and the energy metabolism of epidermis have been examined and subsequently characterised. The system lacks any characteristics of other described amino acid transport systems in other cell types. LÄS MER