Sökning: "amino acid neurotransmitters"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden amino acid neurotransmitters.

1. 1. On amino acid neurotransmitters in the spinal cord motor nuclei

   Författare :Göran Örnung; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :neurotransmitter; aspartate; glutamate; GABA. glycine; homocysteate; taurine; ultrastructure; freeze-substitution; immunocytochemistry; bouton; synaptic input; motoneuron; strech reflex; spinal cord; cat. rat;

   Sammanfattning : Using pre- and post-embedding immunocytochemistry, the distribution of six amino acid neurotransmitter candidates, with special reference to y-amino-butyric acid (GABA), glycine and glutamate was examined in boutons apposing somata and dendrites in the lumbar motor nuclei of the cat spinal cord. The monosynaptic connection between muscle spindle I a afferents and motoneurons regarding content of neuroactive amino acid and complement of amino acid receptors in the postsynaptic membrane was studied in the rat. LÄS MER

3. 2. Immunocytochemical studies of excitatory amino acid neurotransmitters and transporters in the spinal cord and nucleus submedius

   Författare :Stefan Persson; Neurofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurophysiology; neuropsychology; Neurology; VGLUT2; VGLUT1; pain; somatosensory; thalamus; immunogold; glutamate; aspartate; dorsal horn; excitatory amino acids; spinal cord; neurofysiologi; Neurologi;

   Sammanfattning : The amino acid glutamate is today regarded as the main fast excitatory neurotransmitter in the central nervous system and a large body of evidence support that glutamate serves as a neurotransmitter in primary afferent terminals in the spinal cord. Previous evidence also suggests that the closely related amino acid aspartate may serve a similar role in some primary afferent terminals. LÄS MER

4. 3. Unlocking the Role Of Orphan Solute Carrier SLC38A10 In Brain Metabolism : The SLC38A10 transporter in nutrient and metabolic regulation

   Författare :Rekha Tripathi; Robert Fredriksson; Manuel Palacín; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC38A10 transporter; SLC38 family; ER Golgi localization; Amino acid starvation; Nutrient sensing; mTOR signaling; Transcriptomic; Protein array; Metabolomics; Ingenuity Pathway Analysis; Farmaceutisk vetenskap; Pharmaceutical Science; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Membrane transporters are the primary gatekeepers of cells and regulate the transport of nutrients, metabolites, ions, water, and neurotransmitters into and across the human cells. The solute carrier transporters (SLCs) are the most prominent transporters, comprising 430 members divided into 65 subfamilies. LÄS MER

5. 4. On age related changes in axons and glia of the central nervous system

   Författare :Susanna Kullberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Aging; synaptic input; spinal cord; hippocampus; amino acid neurotransmitters; astrocyte; microglia; oligodendroglia; C bouton; cholinergic; monoaminergic; cytokine;

   Sammanfattning : A growing body of evidence shows that phenotypic changes including axon aberrations, rather than loss of neurons, account for behavioral impairments during aging. The present thesis was undertaken to investigate the occurrence of axon aberrations in relation to transmitter identity, glial reaction and sensorimotor disturbances. LÄS MER

7. 5. Neurochemical Signatures for the Evaluation of Disease State and Therapeutic Strategies in Neurodegenerative Diseases: a Magnetic Resonance Spectroscopy Study

   Författare :Sandra Cuellar-Baena; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :Magnetic Resonance Spectroscopy; neurochemical profile; neurodegenerative diseases; gene therapy.;

   Sammanfattning : Magnetic Resonance Spectroscopy (MRS) allows for the quantification of neurotransmitters, antioxidants, energy-metabolism, membrane components and cellular viability markers present in the brain. This technology has been used in preclinical studies and later extended to be used in humans, where it offers an attractive non-invasive approach complementary to other anatomical imaging modalities (e. LÄS MER