Sökning: "amination"

Visar resultat 16 - 20 av 33 avhandlingar innehållade ordet amination.

  1. 16. Targeting to EGF receptors : Preparation and experimental analysis of end-end coupled mEGF-dextran conjugates

    Författare :Qinghai Zhao; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Oncology; Onkologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Sammanfattning : Targeted tumor therapy is to deliver cytotoxic agents selectively to tumor cells. By such delivery, normal tissues receive minimal damage while a therapeutical effect is achieved in tumor. A targetingsystem can be constructed by conjugating a tumor-seeking molecule and toxic agents via a carrier. LÄS MER

  3. 17. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library

    Författare :Fredrik Thorstensson; Ingemar Kvarnström; Charles Hedgecock; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; combinatorial synthesis; metathesis; olefin metathesis; thrombin; HCV; NS3; protease; proline isosteres; inhibitor; Organic synthesis; Organisk syntes;

    Sammanfattning : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. LÄS MER

  4. 18. Palladium-Catalyzed Nucleophilic Substitution of Alcohols : Mechanistic Studies and Synthetic Applications

    Författare :Supaporn Sawadjoon; Joseph Samec; Takao Ikariya; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium; nucleophilic substitution; mechanism; Organic Chemistry; Organisk kemi;

    Sammanfattning : This thesis deals with the palladium-catalyzed nucleophilic substitution of π-activated alcohols in which the C–O bond of a non-manipulated hydroxyl group is cleaved. The thesis is divided in two chapters describing two different catalytic systems. LÄS MER

  5. 19. Making Analogues of Tröger's Base – Fused oligomers, endo/exo isomers and twisted amides

    Författare :Josep Artacho Ruiz; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The centenarian Tröger’s base (TB) was envisaged as scaffold for the construction of tubular-shaped cleft molecules due to its the remarkable structural properties. This endeavor started with the synthesis of the three possible diastereomers of a linear symmetrically fused tris-TB analogue, the anti-anti, the syn-syn, and the syn-anti. LÄS MER

  7. 20. Physical, Chemical and Biochemical Modifications of Industrial Softwood Kraft Lignin for Different Applications

    Författare :Miao Wang; Jiebing Li; Mikael Lindström; Elisabeth Sjöholm; Gunnar Westman; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi; Chemistry;

    Sammanfattning : Various technical lignins, e.g. industrial Softwood Kraft lignin (SKL), are now largely available while they are generally underutilized due to their heterogeneous and complicated structures and/or the poor properties. LÄS MER