Sökning: "amide i"

Visar resultat 1 - 5 av 50 avhandlingar innehållade orden amide i.

  1. 1. Computational infrared spectroscopy : Calculation of the amide I absorption of proteins

    Författare :Cesare Michele Baronio; Andreas Barth; Sander Woutersen; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; infrared spectroscopy; FTIR; simulation; calculation; amide I; transition dipole coupling; F matrix; protein; amyloid β; oligomers; β-helix; Biophysics; biofysik;

    Sammanfattning : Infrared spectroscopy is an important technique that allows to retrieve structural information from the analysis of absorption spectra. The main application of infrared spectroscopy within life science is the study of the amide I band, which is correlated with protein backbone conformation and, consequently, with the secondary structure of proteins. LÄS MER

  2. 2. Group (IV) Metal-Catalyzed Direct Amidation : Synthesis and Mechanistic Considerations

    Författare :Helena Lundberg; Adolfsson Hans; Tom Sheppard; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; catalysis; amide; carboxylic acid; amino acid; titanium; zirconium; hafnium; Organic Chemistry; organisk kemi;

    Sammanfattning : The amide unit constitutes the backbone of proteins, and it is present in a large number of pharmaceutically active molecules, polymeric materials such as nylon and Kevlar, as well as in food additives like aspartame. Amides are produced in enormous amounts every year, thus, environmentally friendly and selective methods for their formation are of great importance. LÄS MER

  3. 3. The choreography of protein vibrations : Improved methods of observing and simulating the infrared absorption of proteins

    Författare :Eeva-Liisa Karjalainen; Andreas Barth; Astrid Gräslund; Timothy A. Keiderling; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Infrared spectroscopy; FTIR; protein; atpase; amyloid; caged compound; amide I; transition dipole coupling; exciton theory; simulation; Molecular biophysics; Molekylär biofysik; Biophysics; biofysik;

    Sammanfattning : The work presented in this thesis has striven toward improving the capability to study proteins using infrared (IR) spectroscopy. This includes development of new and improved experimental and theoretical methods to selectively observe and simulate protein vibrations. LÄS MER

  4. 4. Development of New Chiral Bicyclic Ligands : Applications in Catalytic Asymmetric Transfer Hydrogenation, Epoxidations, and Epoxide Rearrangements

    Författare :Arnaud Gayet; Andersson Pher G.; Hilmersson Göran; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; asymmetric catalysis; transfer hydrogenation; epoxide rearrangement; Organocatalysed epoxidation; chiral ligand; allylic alcohol; kinetic resolution; lithium amide; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis describes the synthesis and application of new chiral bicyclic ligands and their application in asymmetric catalysis. The studies involved: [i] The development of novel chiral bicyclic amino sulfur ligands and their use in transfer hydrogenation. LÄS MER

  5. 5. Fatty acid amide hydrolase - A target for anti-inflammatory therapies?

    Författare :Sandra Holt; Christopher J Fowler; Anders Bucht; Gunnar Tiger; Ruth A Ross; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; FAAH; anandamide; endocannabinoid; pH; inflammation; NSAID; Farmakologi; Pharmacological research; Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : Anti-inflammatory drugs are a widely used class of therapeutic agents, but the use of non-steroidal anti-inflammatory drugs (NSAID) is hampered by their gastrointestinal side-effects. Recent reports that cyclooxygenase-2 inhibitors may cause cardiovascular events underline the importance of identifying new therapeutic strategies for the treatment of inflammation. LÄS MER