Sökning: "alpha7 nicotinic acetylcholine receptor"

Hittade 5 avhandlingar innehållade orden alpha7 nicotinic acetylcholine receptor.

  1. 1. Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer : Roles for the α7nAChR

    Författare :Ann Novotny; Dick Delbro; Eva Ekblad; Högskolan i Kalmar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha7 nicotinic acetylcholine receptor; acetylcholine; colorectal cancer; morphine; nicotine; plasminogen activator inhibitor-1; SLURP-1; Oncology; Onkologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : .... LÄS MER

  3. 2. Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol lowering drugs in Alzheimer's disease

    Författare :Jin Xiu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nicotinic acetylcholine receptor; Alzheimer s disease; glia cells; Abeta; cholesterol; cholesterollowering drugs;

    Sammanfattning : Nicotinic acetylcholine receptors (nAChRs) are involved in the regulation of many processes including synapses regeneration, neurotransmission and neuroprotection in the central nervous system (CNS). There is increasing evidence for the disturbances in nAChRs in Alzheimer's disease (AD). LÄS MER

  4. 3. Beta-amyloid processing and alpha7 neuronal nicotinic acetylcholine receptors in Alzheimer's disease-related mouse models : interactive mechanisms with focus on new drug targets

    Författare :Monika M Hedberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Accumulation of beta-amyloid (Abeta), neuronal loss and changes in neurotransmitter systems, in particular the cholinergic system, are consistent features of Alzheimer s disease (AD). Abeta is thought to play a critical role in the pathogenesis of AD and it has therefore become a target of interest as regards a therapeutic approach. LÄS MER

  5. 4. Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : implications for Alzheimer’s disease

    Författare :Marie M Svedberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD) is the most frequent type of dementia and is characterized neuropathologically by deposition of plaques containing beta-amyloid (Abeta) and by neurofibrillary tangles, of which the main component is hyperphosphorylated tau. The degenerative progression seen in AD is accompanied by disturbances in several neurotransmitter systems, especially the cholinergic neurotransmitter system. LÄS MER

  7. 5. Characterization and expression of subtypes of nicotinic receptors in brain and adrenal medulla : with focus on development, Alzheimer's disease and transgenic animal models

    Författare :Malahat Mousavi Tasouji; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cholinergic nicotinic receptors (nAChRs) seem to play an important role in numerous important physiological processes in brain as well as peripheral tissues of man. In first trimester human brain mRNA levels for the alpha3, alpha4, alpha5, alpha7, beta2, beta3, and beta4 nAChR subunits and binding sites were detected at 5 weeks of gestation. LÄS MER