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Visar resultat 1 - 5 av 9 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Characterization of Pleiotropic Activities of alpha1-Antitrypsin

    Författare :Caroline Sandström; Enheten för kroniska inflammatoriska och degenerativa sjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; alpha1-Antitrypsin deficiency; alpha1-Antitrypsin;

    Sammanfattning : Chronic Obstructive Pulmonary Disease (COPD) is a respiratory disease characterized by chronic inflammatory response in the airways and lung parenchyma that involves the influx of inflammatory, structural cells and mediators. The inflammatory process resulting in lung tissue destruction, emphysema, includes the excess of uninhibited proteases released from inflammatory cells. LÄS MER

  3. 2. Lung function in alpha1-antitrypsin deficiency

    Författare :Eeva Piitulainen; allergologi och palliativ medicin Lungmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha1-antitrypsin deficiency. Lung function. Register. Risk factors. Lung disease. Natural course.; Respiratory system; Andningsorganen;

    Sammanfattning : Hereditary alpha1-antitrypsin (AAT) deficiency predisposes to liver disease and emphysema. The aims of the studies upon which thesis is based were to investigate the natural course of lung function and risk factors for lung disease in AAT-deficient adolescents (PiZZ and PiSZ) and adults (PiZZ), and to study clinical manifestations in AAT-deficient adults. LÄS MER

  4. 3. Arterial wall stiffness in man. On gender differences and abnormalities in insulin dependent diabetes mellitus and alpha1-antitrypsin deficiency

    Författare :Åsa Rydén Ahlgren; Malmö Klinisk fysiologi och nuklearmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sex characteristics.; abdominal aortic aneurysm; arterial stiffness; alpha1-antitrypsin deficiency; ultrasonography; Insulin dependent diabetes mellitus; Clinical physics; radiology; tomography; medical instrumentation; Klinisk fysiologi; radiologi; tomografi; medicinsk instrumentering;

    Sammanfattning : The mechanical properties of major arteries may reflect early manifestations of vascular disease and are also of interest because they are important for cardiac work. Using echo-tracking sonography and blood pressure measurements, arterial stiffness and diameters were investigated in healthy individuals as well as in patients with insulin dependent diabetes mellitus (IDDM) or alpha1-antitrypsin deficiency (alpha1-AT deficiency). LÄS MER

  5. 4. Alpha 1-antitrypsin: A Role in Cancer Progression

    Författare :Inga Zelvyté; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; invasion; neutrophils; cancer cell; Alpha1- antitrypsin; proteinase inhibitors;

    Sammanfattning : Alpha1-antitrypsin (AAT), a circulating single-chain glycoprotein is the most abundant serine proteinase inhibitor in human plasma. AAT is an acute phase protein, its levels increase rapidly to concentrations exceeding 50mM in response to inflammation, infection and malignant diseases. LÄS MER

  7. 5. Alpha1-Antitrypsin: New insights into the biological role in vitro and in vivo

    Författare :Izabela Nita; Enheten för kroniska inflammatoriska och degenerativa sjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Alpha1-Antitrypsin (AAT), an acute-phase glycoprotein produced predominantly in the liver by hepatocytes, but also by macrophages, pulmonary alveolar cells and intestinal epithelial cells, is a member of the SERPIN superfamily (SERine Protease INhibitors), and is one of the major inhibitors of neutrophil elastase in human plasma. Although AAT plays a critical role in regulating inflammation by inhibiting neutrophil serine proteases, recent studies suggest that AAT exhibits much broader anti-inflammatory activity. LÄS MER