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Visar resultat 1 - 5 av 49 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Alpha-Synuclein Oligomers : Cellular Mechanisms and Aspects of Antibody Treatment

   Författare :Gabriel Gustafsson; Martin Ingelsson; Joakim Bergström; Anna Erlandsson; Tiago F Outeiro; Marina Romero-Ramos; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; Alpha-synuclein; Aggregation; Oligomers; Monoclonal Antibody; Glia; Astrocyte; Immunofluorescence; Medicinsk vetenskap; Medical Science;

   Sammanfattning : In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), aggregated α-synuclein deposit inside cells within the brain. Smaller soluble α-synuclein aggregates, oligomers, are present both intra- and extracellularly. LÄS MER

3. 2. Characterization of Physiological and Pathological Alpha-Synuclein : Implications for Parkinson’s Disease and Related Disorders

   Författare :Leire Almandoz Gil; Joakim Bergström; Martin Ingelsson; Kostas Vekrellis; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Alpha-synuclein; Aggregation; Parkinson’s disease; Dementia with Lewy bodies; Oxidative stress; Antibodies; Synapses; SNARE; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Aggregated alpha-synuclein is the main component of Lewy bodies and Lewy neurites, intraneuronal inclusions found in the brains of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) patients (synucleinopathies). Alpha-synuclein is a presynaptic protein, which is most commonly an unfolded monomer in its physiological state. LÄS MER

4. 3. GDNF and alpha-synuclein in nigrostriatal degeneration

   Författare :Maria Chermenina; Ingrid Strömberg; Guido Nikkhah; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; GDNF; ventral mesencephalon; lateral ganglionic eminence; alpha-synuclein; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

   Sammanfattning : Parkinson’s disease is a common neurological disorder with a complex etiology. The disease is characterized by a progressive loss of dopaminergic cells in the substantia nigra, which leads to motor function and sometimes cognitive function disabilities. LÄS MER

5. 4. Pathogenic effects of alpha-synuclein: modifications and toxicity

   Författare :Natalie Landeck; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :Parkinson s disease; adeno-associated viral vector; animal models; alpha-synuclein; substantia nigra; dopaminergic neurons; phosphorylation; aggregation; toxicity;

   Sammanfattning : Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate formation. LÄS MER

7. 5. Alpha-synuclein: pathology, peripheral expression, and environmental interactions

   Författare :Caroline Haikal; Neural plasticitet och reparation; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease PD ; alpha-synuclein; Bacterial amyloids; Synucleinopathies; Gastrointestinal GI tract; DMSO;

   Sammanfattning : .... LÄS MER