Sökning: "alpha-secretase"

Visar resultat 6 - 10 av 10 avhandlingar innehållade ordet alpha-secretase.

  1. 6. The role of estrogen regulation in brain development and neurodegeneration

    Författare :Linda Nord; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogen is a steroid hormone which regulates neuronal control of reproduction. It has other important roles in the central nervous system (CNS), including trophic effects on dendritic spine morphology that provide structural plasticity. LÄS MER

  3. 7. Targeted Abeta proteomics - A tool to study the pathogenesis of Alzheimer’s disease

    Författare :Erik Portelius; Göteborgs universitet; []
    Nyckelord :Alzheimer’s disease; Cerebrospinal fluid; Immunoprecipitation; Mass spectrometry; beta-amyloid;

    Sammanfattning : Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder of the central nervous system. Diagnosis and monitoring of sporadic AD has long depended on clinical examination of individuals with end-stage disease. LÄS MER

  4. 8. Distribution and pathophysiological role of amyloid precursor protein and presenilin 1 : characterization in rats and in vitro studies on the pathogenic arctic mutation

    Författare :Camilla Nilsberth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease is the most common form of dementia that presents a growing dilemma worldwide. Alzheimer's disease is neuropathologically characterized by cerebral atrophy accompanied by deposition of senile plaques and neurofibrillary tangles. LÄS MER

  5. 9. Apolipoprotein E and Alzheimer's diseases : signals and effects

    Författare :Ángel Cedazo-Minguez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's Disease (AD) is the most frequent cause of dementia in the elderly. A diagnosis of AD is confirmed post-mortem by the accumulation of neuritic plaques (NP) and neurofibrillary tangles (NFTs) in brain tissue. LÄS MER

  7. 10. Alzheimer´s disease-related amyloid precursor protein and presenlin genes : normal function and pathophysiology

    Författare :Fiona Flood; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is characterised neuropathologically by the presence of plaques and tangles in the brain. AD can be sub-grouped into early onset (EOAD, age of onset ... LÄS MER