Sökning: "alpha-lactalbumin"

Visar resultat 11 - 15 av 15 avhandlingar innehållade ordet alpha-lactalbumin.

1. 11. Role of HAMLET and metabolism in treatment and pathogenesis of pneumococci

   Författare :Goutham Vansarla; Malmö Experimentell infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus pneumoniae; Antibiotic resistance; Alpha-lactalbumin; HAMLET; Biofilms; Bacterial metabolism; Immunomodulatory effects.;

   Sammanfattning : Antimicrobial resistance (AMR) is one of the principle public health problems in the 21st century, threatening the available treatment strategies for bacterial infections. Here, we present a human protein-lipid complex, HAMLET (human alpha-lactalbumin made lethal to tumor cells) purified from human milk as a potential therapeutic agent which has both tumoricidal and bactericidal activity. LÄS MER

3. 12. HAMLET - In vivo effects and mechanisms of tumor-cell death

   Författare :Lotta Gustafsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper; Biomedical sciences; proteasome stress; HAMLET; human milk; tumor-cell death; clinical trial; rat xenograft model; skin papilloma; glioblastoma;

   Sammanfattning : HAMLET (human alpha-lactalbumin made lethal to tumor cells), a molecular complex derived from human milk, is an interesting new tool in cancer research since it induces programmed cell death in tumor cells while leaving normal, differentiated cells unharmed. The in vivo effects of HAMLET were studied in a rat xenograft model of human glioblastoma. LÄS MER

4. 13. Mechanisms of apoptosis induced by a protein complex isolated from human milk : with focus on the role of mitochondria

   Författare :Camilla Köhler; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Human milk contains a protein complex comprising of a folding variant of human alpha-lactalbumin and oleic acid (C18:1). Both, a milk fraction containing this complex (MAL, for multimeric (alpha- lactalbumin). LÄS MER

5. 14. Antibiotic resistance and pathogenesis of Streptococci with focus on Group A Streptococci

   Författare :Feiruz Alamiri; Malmö Experimentell infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotika resistens; Bröstmjölk; Luftvägsinfektioner; Biofilm bildning; Internalisering; Persistens; HAMLET; Streptokocker; kolonisering; Streptococcus pneumoniae; biofilm formation; Internalisation; Persistence; Antibiotic resistance; Streptococcus pyogenes; Streptococcus agalactiae; HAMLET; Breast milk; Proteome; Virulence factors; Colonization;

   Sammanfattning : Multi-drug resistant (MDR) infections remain the leading cause of death worldwide. MDR infections caused by Streptococcus pneumoniae (Spn), Streptococcus pyogenes (GAS) and Streptococcus agalactiae (GBS) are considered global threats to human health due to increased spread of antibiotic resistance and limited treatment options. LÄS MER

7. 15. Structure and Function of HAMLET: Epitopes, Membrane Interactions and Molecular Recognition

   Författare :Chin Shing Ho; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded human alpha-lactalbumin and oleic acid that kills many different types of tumor cells and shows therapeutic efficacy in animal models and clinical studies. This thesis aims to (1) elucidate the structure of HAMLET and the exposure of biologically active domains, (2) define the contribution of lipids to the tumoricidal effect of HAMLET, (3) characterize the membranes response to HAMLET and the perturbation of membrane associated signaling cascades, (4) use proteomic screens to identify conserved features of HAMLET targets in tumor cells. LÄS MER