Sökning: "alpha-actinin"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet alpha-actinin.

  1. 1. Molecular characterization and evolution of alpha-actinin : from protozoa to vertebrates

    Författare :Ana Virel; Lars Backman; Kristina Djinovic-Carugo; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; alpha-actinin; evolution; spectrin repeat; intragene duplication; phylogenetic tree; spectrin superfamily; Biochemistry; Biokemi;

    Sammanfattning : alpha-actinin is a ubiquitous protein found in most eukaryotic organisms. The ability to form dimers allows alpha-actinin to cross-link actin in different structures. In muscle cells alpha-actinin is found at the Z-disk of sarcomeres. LÄS MER

  3. 2. Alpha-actinin - an amazing journey through time and species

    Författare :Barbara Addario; Lars Backman; Yari Ylänne; Umeå universitet; []
    Nyckelord :;

    Sammanfattning : In eukaryotes, the actin cytoskeleton plays an important role in a large variety of cellular events. Its reorganization is regulated by a plethora of actin-modulating proteins, such as α-actinin. α-actinin is a ubiquitous actin-binding protein that belongs to the spectrin superfamily. LÄS MER

  4. 3. Mechanisms of HAMLET-induced cancer cell death

    Författare :Sonja Aits; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-actinin; prohibitin; alpha-lactalbumin; HAMLET; cancer; cell death; autophagy; focal adhesions; c-Myc; hexokinase; glycolysis;

    Sammanfattning : HAMLET, a complex of α-lactalbumin and oleic acid, preferentially kills cancer cells and is also effective in vivo. HAMLET causes apoptosis but cells die even if this pathway is inhibited. Thus, the role of autophagy, an alternative cell death pathway, was examined. LÄS MER

  5. 4. Cellular interactions of HAMLET and their role in cell death

    Författare :Maria Trulsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HAMLET; alpha-lactalbumin; cancer; cell death; ion channels; p38; cell detachment; alpha-actinin; endocytosis; macropinocytosis; c-Myc; glycolysis;

    Sammanfattning : HAMLET is a protein-lipid complex that selectively kills tumor cells. In this thesis, we identified new mechanisms, whereby HAMLET initiates and executes tumor cell death. HAMLET targets several cellular compartments ranging from the plasma membrane to the nucleus. LÄS MER

  7. 5. Ultrastructural studies of the blood-urine barrier in proteinuric states

    Författare :Fredrik Dunér; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The kidneys filter enormous amounts of blood every day, removing excess fluid and waste products while retaining cells and large proteins in the circulation. The podocytes with their foot processes and slit diaphragms (SD) are important components of the renal filter and the barrier function. LÄS MER