Sökning: "alpha-1"

Visar resultat 1 - 5 av 84 avhandlingar innehållade ordet alpha-1.

  1. 1. Alpha-1-microglobulin: Innate defence against pathological oxidation

    Författare :Magnus Gram; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-1-microglobulin; pathological oxidation; hemoglobin; heme; radiation; oxidation; ROS; hemoglobin and heme antagonist; radical scavenger;

    Sammanfattning : Oxidative stress has been implicated as an important factor in the progression of many diseases. An imbalance in the redox-system may cause oxidation of cells and molecules, which might subsequently lead to tissue damage. LÄS MER

  3. 2. Structure and distribution of alpha-1-microglobulin proteins

    Författare :Tord Berggård; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteins; lysine; chromophore; placenta; immunohistochemistry; albumin; prothrombin; plasma; bikunin; lipocalin; alpha-1-microglobulin; protein HC; enzymology; Proteiner; enzymologi;

    Sammanfattning : This thesis describes studies of the structure and tissue distribution of alpha-1-microglobulin (a1-m), a member of the lipocalin protein superfamily with immunosuppressive properies. It was shown that a1-m appears in human plasma in five major forms. LÄS MER

  4. 3. Alpha-1-microglobulin, heme-binding protein, reductase and antioxidant

    Författare :Maria Allhorn; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reduction; inflammation; chronic ulcers; collagen; low density lipoproteins; Medicin människa och djur ; Medicine human and vertebrates ; antioxidation; heme; hemoglobin; alpha-1-microglobulin; lipocalin;

    Sammanfattning : This thesis describes structural and functional studies of alpha-1-microglobulin (a1m), a 26 kDa plasma and tissue protein that is evolutionarily well-conserved and belongs to the lipocalin superfamily. The lipocalins are polypeptides of 160-190-amino acids that are folded into an 8-stranded beta-barrel forming a pocket with a hydrophobic interior. LÄS MER

  5. 4. Alpha-1-antitrypsin deficiency (PiZ): Clinical studies with special regard to hepatic and vasculitic disorders

    Författare :Abdul-Nasser Elzouki; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastro-enterology; systemic vasculitis; small-vessel vasculitis; serpins; genetic hemochromatosis; chronic hepatitis C; chronic liver disease; Alpha-1-antitrypsin deficiency; alpha-1-antichymotrypsin deficiency; Gastroenterologi; Urology; nephrology; Urologi; nefrologi;

    Sammanfattning : Homozygous alpha-1-antitrypsin (AAT)deficiency (PiZZ) is known to predispose to emphysema and chronic liver disease (CLD). The overall aim of the studies upon which this thesis is based was to investigate extra-pulmonary disease manifestations of AAT deficiency with special reference to hepatic and vasculitic disorders. LÄS MER

  7. 5. Severe and moderate alpha-1-antitrypsin deficiency at the age of 30

    Författare :Elisabeth Bernspång; allergologi och palliativ medicin Lungmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cohort; screening; alpha-1-antitrypsin; lung function; CT densitometry; liver;

    Sammanfattning : Alpha-1-antitrypsin (AAT) is a glycoprotein synthesised in the liver. Its main role is to protect lung tissue from destruction by neutrophil elastase. In severe (PiZZ) AAT deficiency, there is an increased risk of emphysema, especially in smokers. LÄS MER