Sökning: "allelic"

Visar resultat 1 - 5 av 186 avhandlingar innehållade ordet allelic.

  1. 1. Targeting allelic loss in colorectal cancer

    Författare :Verónica Rendo; Tobias Sjöblom; Nickolas Papadopoulos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; gene editing; loss of heterozygosity; targeted therapy; whole genome sequencing;

    Sammanfattning : Targeted cancer therapy exploits molecular differences between tumor and normal cells to selectively kill cancer cells. Whereas targeting of activated oncogenes has proved clinically useful, few current therapies exploit loss-of-function mutations in tumor suppressor genes or in the genome at large. LÄS MER

  3. 2. Modelling Allelic and DNA Copy Number Variations using Continuous-index Hidden Markov Models

    Författare :Susann Stjernqvist; Matematisk statistik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hidden Markov models; DNA copy number; allelic copy number; Markov chain Monte Carlo;

    Sammanfattning : In human cells there are usually two copies of each chromosome, but in cancer cells abnormalities could exist. The differences consist of segments of chromosomes with an altered number of copies. There can be deletions as well as amplifications and the lengths of the segments can also vary. LÄS MER

  4. 3. Exploring the Functional Plasticity of Human Glutathione Transferases : Allelic Variants, Novel Isoenzyme and Enzyme Redesign

    Författare :Ann-Sofie Johansson; Philip Board; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Glutathione transferases (GSTs) make up a superfamily that is involved in the cellular defense against various reactive compounds by catalyzing the conjugation of glutathione to electrophilic centra. Members of this family have also been implicated in different facets of biological signaling. LÄS MER

  5. 4. Monogenic Traits Associated with Structural Variants in Chicken and Horse : Allelic and Phenotypic Diversity of Visually Appealing Traits

    Författare :Freyja Imsland; Leif Andersson; Gabriella Lindgren; Kerstin Lindblad-Toh; Eiríkur Steingrímsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Structural variation; Pigmentation; Domestication; Equids; MNR2; CCDC108; STX17; TBX3; Grey; Dun; non-dun; Rose-comb; Chicken; Genetic mapping; Phenotyping; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Domestic animals have rich phenotypic diversity that can be explored to advance our understanding of the relationship between molecular genetics and phenotypic variation. Since the advent of second generation sequencing, it has become easier to identify structural variants and associate them with phenotypic outcomes. LÄS MER

  7. 5. Analysis of Allelic Imbalance in DMBA-induced Rat Fibrosarcomas

    Författare :Åsa Sjöling; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER