Sökning: "allelic exclusion"
Hittade 5 avhandlingar innehållade orden allelic exclusion.
1. Regulation of B cell development by antigen receptors
Sammanfattning : The developmental processes of lymphopoiesis generate mature B lymphocytes from hematopoietic stem cells through increasingly restricted intermediates. Networks of transcription factors regulate these cell fate choices and are composed of both ubiquitously expressed and B lineage-specific factors. LÄS MER
2. T cells in Autoimmunity: studies on murine type II collagen-induced arthritis
Sammanfattning : Collagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis, in which autoimmunity is induced by immunization with type II collagen (CII), a cartilage-specific protein. In the present work, alpha/beta T cells were shown to be required for CIA and for the production of anti-CII IgG antibodies, whereas gamma/delta T cells were neither necessary nor sufficient for development of CIA. LÄS MER
3. B lymphocytes in solid human malignancies
Sammanfattning : Cancer remains one of the leading causes of death worldwide. Modern treatments such as immunotherapy and neoadjuvant chemotherapy exhibit promising results. However better understanding of the treatments may lead to optimizations and consequently better prognosis. LÄS MER
4. Juvenile myoclonic epilepsy : clinical, genetic, clinical pharmacological, and neurophysiological studies
Sammanfattning : Juvenile myoclonic epilepsy (JME) has been considered to be a discrete phenotype. Evidence from segregation analysis and twin studies suggest that JME is a genetically determined disease, and two previous linkage studies of separately ascertained kindreds have suggested that a JME locus, EJM 1, resides on chromosome 6p close to the HLA region. LÄS MER
5. Variant antigens at the infected red cell surface in Plasmodium falciparum malaria
Sammanfattning : Disease severity in Plasmodium falciparum infections is, to a large extent, a consequence of the parasite's efficient escape from die human host defences. Sequestration and antigenic variation are two evasion mechanisms featured by P.falciparum. LÄS MER