Sökning: "alkyl iodides"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden alkyl iodides.

  1. 1. Synthesis of 11C-labelled Alkyl Iodides : Using Non-thermal Plasma and Palladium-mediated Carbonylation Methods

    Författare :Jonas Eriksson; Bengt Långström; Philip H. Elsinga; Uppsala universitet; []
    Nyckelord :Organic chemistry; isotopic labelling; carbon-11; alkyl iodides; acrylamides; specific radioactivity; carbonylation; carbon monoxide; non-thermal plasma; PET; Organisk kemi;

    Sammanfattning : Compounds labelled with 11C (β+, t1/2 = 20.4 min) are used in positron emission tomography (PET), which is a quantitative non-invasive molecular imaging technique. It utilizes computerized reconstruction methods to produce time-resolved images of the radioactivity distribution in living subjects. LÄS MER

  3. 2. The chemistry of organic iodides under severe nuclear accident conditions in LWRs

    Författare :Sabrina Tietze; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic iodides; Wet-filter system scrubber ; Chlorine; Volatile iodine source term; Severe nuclear accident; Cables; Sorption; Containment; Paint; Iodine; LWR; Radiolysis;

    Sammanfattning : For many countries nuclear fission is an important part of their energy portfolio. However, a great concern is the occurrence of nuclear reactor accidents, which can result in the emission of radioactivity into the environment. LÄS MER

  4. 3. Formation, partitioning and interactions of organic iodides under severe nuclear accident conditions

    Författare :Sabrina Tietze; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Epoxy paint; Methyl iodide; Iodine source term; Organic iodides; Severe nuclear accidents;

    Sammanfattning : During severe nuclear reactor accidents such as Chernobyl or Fukushima large amounts of radioactive iodine can be released in form of inorganic and organic iodine species into the environment. Volatile radioactive iodine species are harmful to human health when inhaled. LÄS MER

  5. 4. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions : PET Tracer Development Targeting the Vesicular Acetylcholine Transporter

    Författare :Sara Roslin; Mats Larhed; Gunnar Antoni; Jonas Eriksson; Luke Odell; Victor Pike; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Carbonylation; palladium; carbon-11; radiochemistry; positron emission tomography; vesicular acetylcholine transporter; vesamicol; alkyl halide; oxidative carbonylation; acylamidine; oxadiazole; heterocycle; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. LÄS MER

  7. 5. Photoinitiated Radical Carbonylation Using [11C]Carbon Monoxide : 11C-Labelling of Aliphatic Carboxylic Acids, Esters, and Amides

    Författare :Oleksiy Itsenko; Bengt Långström; Tor Kihlberg; Chryssostomos Chatgilialoglu; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; 11C-labelling; radicals; carbonylation; carbon monoxide; solvent effects; sensitizers; sulfoxides; WAY-100635; PET; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : One-step photoinitiated free radical carbonylation was employed for the rapid (5–7 min) labelling of aliphatic carboxylic acids, esters, and amides with a short-lived positron emitter 11C (t½ = 20.3 min) at the carbonyl position. The labelled compounds were synthesized from alkyl iodides (0.05–0. LÄS MER