Sökning: "alfa 1 at"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden alfa 1 at.

  1. 1. Structural Insights into Botulinum Neurotoxins and the ALFA-tag System : Structural and Functional Studies of Proteins Related to the Botulinum Neurotoxins and Design of a Novel Epitope Tag

    Författare :Markel Martínez-Carranza; Pål Stenmark; Thomas Binz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; botulinum neurotoxin; Biochemistry; biokemi;

    Sammanfattning : This thesis is divided into two sections; the first part describes our work in the field of botulinum neurotoxins (presented in papers I, II, III, and manuscript IV) and the second part summarizes our work involving the design of a new biochemical tool (presented in paper V).Botulinum neurotoxins (BoNTs) produced by the anaerobic bacterium Clostridium botulinum are the most poisonous substances known to date. LÄS MER

  3. 2. Clinical course and prognosis of individuals with severe alpha 1-antitrypsin deficiency (PiZZ)

    Författare :Hanan Tanash; allergologi och palliativ medicin Lungmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lung transplantation; occupation exposure; siblings; smoking; standardized mortality ratio; survival.; causes of death; alpha-1-antitrypsin deficiency;

    Sammanfattning : Severe alpha-1 antitrypsin deficiency (AATD) is a genetic disorder associated with increases risk of developing of chronic obstructive lung disease and liver disease. The Swedish National Registry for individuals with severe AATD was started 1991.Up to October 2008, a total of 1349 individuals were included in the registry. LÄS MER

  4. 3. Haemophilia A - In pursuit of optimised outcomes via personalised treatment

    Författare :Alexandros Arvanitakis; Malmö Klinisk koagulationsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Haemophilia A (HA) is a hereditary bleeding disorder, characterised by deficiency of coagulation factor VIII (FVIII). Repeated joint bleeds can lead to permanent joint damage. FVIII replacement therapy has a high cost and can reduce but not completely prevent bleeding. LÄS MER

  5. 4. Från ägarmakt under ansvar till företagsledarmakt. En studie över maktförskjutningen hos tre svenska verkstadsaktiebolag

    Författare :Sven Olof Arlebäck; Ekonomisk-historiska institutionen; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Ekonomisk och social historia; Social and economic history; Board fees; Board meetings; Board members; Board of Directors; Liability; Power; Sweden; Public limited company;

    Sammanfattning : The dissertation is confined to the formal work of the boards of the parent companies as recorded in the approved minutes of meetings at Alfa Laval AB, Atlas Copco AB and Kockums Mekaniska Verkstads AB and is based on the Companies Law applying in Sweden since 1848. The study covers the time from the establishment of the joint stock company up to the ordinary general meeting of 1980 (1979 in the case of Kockums). LÄS MER

  7. 5. Chronic Achilles tendon rupture - surgical reconstruction and post-operative outcomes

    Författare :Niklas Nilsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic Achilles tendon rupture; Semitendinosus graft; Tissue sample; Achilles tendon re-rupture; Surgical repair; Gastrocnemius aponeurosis free flap; Health economics; Patient-reported outcome measurements;

    Sammanfattning : When the treatment of Achilles tendon ruptures is delayed by more than 4 weeks, the rupture is classified as chronic. This thesis aims to examine the postoperative outcome of chronic Achilles tendon ruptures treated surgically in terms of long-term functional outcomes, patient-reported outcome measurements, biomolecular changes, and economic cost. LÄS MER