Sökning: "aleksandra"

Visar resultat 1 - 5 av 52 avhandlingar innehållade ordet aleksandra.

  1. 1. Epidemiology of osteoarthritis in Sweden. Register and cohort studies on prevalence and mortality

    Författare :Aleksandra Turkiewicz; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epidemiology; Osteoarthritis; Knee; Hip; Radiography; Mortality; Registers; Missing data;

    Sammanfattning : Osteoarthritis (OA) is the most common form of arthritis and often causes pain and functional impairment. Despite its high burden on society, knowledge about the occurrence of OA and its associated mortality is sparse. LÄS MER

  3. 2. Exploring molecular interactions between polypeptide conjugates and protein targets : Manipulating affinity by chemical modifications

    Författare :Aleksandra Balliu; Lars Baltzer; Oliver Seitz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polypeptide conjugates; protein targets; molecular recognition; affinity enhancement; conjugation;

    Sammanfattning : In this thesis molecular interactions between polypeptide conjugates and protein targets were investigated. Polypeptides were derivatized with small organic molecules, peptides and oligonucleotides. New strategies were developed with the aim to increase affinities for proteins of biological interest. LÄS MER

  4. 3. Genetic differences in neuropathy and opioid responses in rats

    Författare :Aleksandra Bulka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Allodynia; genetic difference; neuropathic pain; NMDA-receptor; opioids; rat strains; pharmacokinetics; tolerance.;

    Sammanfattning : The studies examined mechanisms and treatments of experimental neuropathic pain with particular emphasis on the differences between rat strains and sub-strains in basal nociceptive sensitivity, development of neuropathic behaviors and sensitivity to opioid analgesia. In order to study the mechanisms that mediate mechanical allodynia (touch-evoked pain) following ischemic nerve injury to the sciatic nerve in rats, the myelinated primary afferents have been examined in the injured and intact nerves. LÄS MER

  5. 4. Hyperconjugation in Group 14 Organic Compounds : Design and Property Investigations

    Författare :Aleksandra Denisova; Henrik Ottosson; Thomas Müller; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 1; 4-disilacyclohexa-2; 5-diene; aromaticity; computational chemistry; conjugation; cross-hyperconjugation; hyperconjugation; group 14 elements; organosilicon chemistry; silole;

    Sammanfattning : Nowadays π-conjugated molecules are widely used as materials for devices in organic and molecular electronics. This is due to the ability of such molecules to conduct electricity. However, π-conjugation leads to molecular rigidness and associated lower solubility, which limits possible applications. LÄS MER

  7. 5. Clinical consequences of pancreatic exocrine insufficiency

    Författare :Aleksandra Hedström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Chronic pancreatitis (CP) is characterized by a chronic inflammation with fibrosis and irreversible morphological changes that can result in permanent structural changes with a loss of exocrine and endocrine pancreas function. Exocrine dysfunction leads to reduced production of pancreatic digestive enzymes which is the reason of maldigestion and malabsorption of ingested nutrients like fats, microelements, vitamins and proteins which can lead to osteopathy. LÄS MER