Sökning: "aldo-keto reductase"

Hittade 5 avhandlingar innehållade orden aldo-keto reductase.

  1. 1. The GRE3 encoded aldo-keto reductase and its influence on xylose fermentation in recombinant Saccharomyces cerevisiae strains

    Författare :Karin Träff; Teknisk mikrobiologi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biochemical technology; Biokemisk teknik; dihydroxyacetone phosphate; xylose reductase; xylose; xylose isomerase; GRE3; Saccharomyces cerevisiae; aldo-keto reductase;

    Sammanfattning : The aim of the work presented in this thesis was to improve ethanol formation from xylose in recombinant Saccharomyces cerevisiae strains. This was achieved by decreasing the xylitol by-product formation. Gre3p is the major xylose-reducing enzyme in S. cerevisiae. LÄS MER

  3. 2. Enzymatic Reduction of Ketones

    Författare :Magnus Carlquist; Teknisk mikrobiologi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; inhibition; flavonoids; anthracyclines; human carbonyl reductase 1; kinetic resolution; Asymmetric bioreduction; bicyclic diketones; Saccharomyces cerevisiae; Escherichia coli; AKR; SDR;

    Sammanfattning : Methods have been studied for the production of chiral alcohols, which are of importance in organic synthesis of pharmaceuticals, agro-chemicals and fragrances, etc., through the enzymatic or microbial reduction of ketones. LÄS MER

  4. 3. Malignant pleural mesothelioma : novel biomarkers and related pathways

    Författare :Filip Mundt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malignant mesothelioma is an asbestos induced cancer that is difficult to diagnose. Several studies have combined biomarkers to improve mesothelioma diagnosis, but with moderate success, and there is a need for new mesothelioma biomarkers. The tumour is often resistant to treatment and most patients will survive less than a year. LÄS MER

  5. 4. Anthracycline pharmacodynamics and pharmacokinetics in acute myeloid leukemia

    Författare :Alex Bogason; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The goal of this thesis has been to study pharmacodynamics and pharmacokinetics of anthracyclines in acute myeloid leukemia (AML) with the ultimate goal to improve chemotherapy: 1. By studying the relation between daunorubicin (DNR) and idarubicin (IDA) uptake in vitro and in vivo and apoptosis in vitro in leukemic cells isolated from patients with AML. LÄS MER

  7. 5. Sample preparation and mass spectrometry in proteome studies

    Författare :Daniel Hirschberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Proteome studies aim to link gene to function. Instead of screening for function in a specific protein as in classical protein chemistry, proteins are now screened against a specific phenotype, disease or metabolic state. LÄS MER