Sökning: "aldehydes"

Visar resultat 21 - 25 av 150 avhandlingar innehållade ordet aldehydes.

1. 21. Development of New Methodology in Organic Synthesis: Lewis Acid-Mediated Rearrangements of Ammonium Ylides and Addition of 1, 3-bis(silyl) propenes to Aldehydes

   Författare :Pavel Tuzina; Peter Somfai; Ari Koskinen; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric; amino acid; ammonium ylide; Lewis acid; microwave irradiation; Organic synthesis; Organisk syntes;

   Sammanfattning : This thesis deals with the development of new methodologies in organicsynthesis. The main focus is on the development of Lewis acid-mediated [1,2]-rearrangements of ammonium ylides and the novel addition of 1,3-bis(silyl)propenes to carbonyl compounds. LÄS MER

3. 22. Aldehyde toxicity in human oral epithelium

   Författare :Jan Anders Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Oral epithelium; cell cultures; toxicity; transformation; aldehydes; thiols; ADH3;

   Sammanfattning : Human oral epithelium is an established target for aldehyde toxicity, including from usage of tobacco, intake of foods and fluids, leaching of dental materials, and from mouth inhalation of aldehydes in the work environment. Following establishment of culture/exposure protocols for oral cell cultures, toxicity mechanisms and risk of malignant transformation from aldehyde exposure was investigated, including the metabolic defense offered by alcohol dehydrogenase 3 (ADH3) against formaldehyde toxicity. LÄS MER

4. 23. Characterization of α-synuclein oligomers : Implications for Lewy Body Disorders

   Författare :Thomas Näsström; Martin Ingelsson; Joakim Bergström; Lars Lannfelt; Poul Henning Jensen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Alpha-synuclein; Lewy bodies; Oligomers; Reactive aldehydes; monoclonal antibody; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy are disorders featuring accumulation of Lewy bodies in brain. The main component of these large insoluble intracellular inclusions is the presynaptic protein alpha-synuclein (α-synuclein). LÄS MER

5. 24. Natural Product Synthesis and Development of Novel Reaction Methodology

   Författare :Jakob Danielsson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; perophoramidine; communesin; quaternary stereocenter; Diels-Alder; 1; 2-asymmetric induction; polar Felkin-Anh; Cornforth-Evans; Mukaiyama aldol; 3-dipolar cycloaddition; azomethine ylide; 2-amino alcohol; anti-α-amino-β-hydroxy ester;

   Sammanfattning : This thesis deals with the development of new reaction methodology for stereoselective synthesis, as well as total synthesis of natural products and investigations of the stereochemical outcome in the Mukaiyama aldol reaction. Chapter 2 describes efforts made towards the total synthesis of the oxindole natural products perophoramidine and the communesin. LÄS MER

7. 25. Olefins from carbonyls : Development of new phosphorus-based cross-coupling reactions

   Författare :Nicolas Daniele D'Imperio; Sascha Ott; Carlos Romero-Nieto; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; olefins; carbonyl olefination; phosphaalkenes; stereoselective synthesis; Wittig; Horner-Wadsworth-Emmons; McMurry;

   Sammanfattning : Olefins, compounds containing C=C double bonds, are omnipresent in nature and serve as useful starting materials for various chemical modifications. Olefins are of crucial importance in Medicinal Chemistry and are also present in essential objects like dyes, polymers and plastics. LÄS MER