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Visar resultat 16 - 20 av 269 avhandlingar innehållade ordet aktivering.
16. Studies on the Role of Apoptosis in Kidney Diseases
Sammanfattning : Apoptosis is one of the most common types of cell death. Under physiological conditions, it plays an essential role in removal of damaged and potentially harmful cells. Excessive apoptosis has however been linked to a number of diseases including proteinuric kidney disease and DKD, and is believed to enhance the disease progression. LÄS MER
17. ADP regulation of insulin secretion and beta-cell apoptosis
Sammanfattning : The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were shown in both mouse pancreatic islets and isolated β-cells using real-time PCR quantification. LÄS MER
18. Evaluation and Mitigation of Industrial Fire Hazards
Sammanfattning : A tool suitable for conducting industrial fire and explosion hazard analysis is presented, together with an identification of weak links in the hazard evaluation chain. For some of the weak links additional research has been carried out. LÄS MER
19. How can p53 induce differentiation of leukemic cells?
Sammanfattning : The terminal differentiation of leukemic cells is closely connected to their death. The concept of differentiation therapy originates from the idea that forced maturation of leukemic cells could induce cell death without the side-effects that are provoked by ordinary chemotherapy. LÄS MER
20. Activation of human B cells with the Moraxella catarrhalis IgD-binding protein MID
Sammanfattning : Moraxella catarrhalis is a respiratory tract pathogen that causes significant health problems, including acute otitis media in children, lower respiratory tract infections in adults and the elderly and sinusitis in both children and adults. The interest in M. LÄS MER