Sökning: "agonists"

Visar resultat 21 - 25 av 288 avhandlingar innehållade ordet agonists.

  1. 21. Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

    Författare :Charlotta Wallinder; Anders Hallberg; Mathias Alterman; Anders Karlén; Elizabeth E. Sugg; Uppsala universitet; []
    Nyckelord :AT2 receptor agonist; AT2 receptor antagonist; Ang II peptidomimetics;

    Sammanfattning : The G protein-coupled receptors (GPCRs) are important targets in drug discovery. In several cases, the endogenous ligands that activate the GPCRs of pharmaceutical interest are peptides. LÄS MER

  3. 22. GABA signaling regulation by GLP-1 receptor agonists and GABA-A receptors modulator

    Författare :Omar M. Babateen; Bryndis Birnir; Lena Eliasson; Uppsala universitet; []
    Nyckelord :Neuroscience; Neurovetenskap;

    Sammanfattning : GABA (γ-aminobutyric acid) is the main neuroinhibitory transmitter in mammalian brains.  It binds to GABA-A and GABA-B receptors. The GABA-A receptors are ligand-gated chloride channels. A variety of GABA-A receptor agonists and antagonists have been developed to study the GABA-mediated inhibition and to explore new medications. LÄS MER

  4. 23. Synthesis and Structure-Activity Relationship. Studies of Non-Peptidic Urotensin II Receptor Agonists

    Författare :Fredrik Lehmann; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  5. 24. Evolution of Membrane Bound Proteins and their Ligands : The Melanocortin (MC) Receptor Inverse Agonists AgRP2, ASIP2, Drug/Metabolite Transporters, and SPNS1

    Författare :Åke Västermark; Helgi Schiöth; Arne Elofsson; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : Integral membrane proteins play a key role hormonal and neuronal signaling. Transmembrane helix (TM) proteins form about 27% of the human proteome. Furthermore, 44% of the human drug targets are receptors, and 19% of these are seven-transmembrane domain receptors (GPCRs), which constitute 4% of the entire protein-coding genome. LÄS MER

  7. 25. Nicotinic and muscarinic receptors in Alzheimer's disease : studies of receptor subtype impairments and modulation by cholinesterase inhibitors and nicotinic agonists

    Författare :Ulrika Warpman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER