Sökning: "agonists"

Visar resultat 11 - 15 av 288 avhandlingar innehållade ordet agonists.

  1. 11. Galanin receptor : studies with site-directed mutagenesis, agonists and antagonists

    Författare :Kalev Kask; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  3. 12. Chemical and bioanalytical characterisation of PAH-contaminated soils : identification, availability and mixture toxicity of AhR agonists

    Författare :Maria Larsson; Magnus Engwall; Jessika Hagberg; Peter Haglund; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polycyclic aromatic compounds; Soil; Risk assessment; Mixture studies; AhR-mediated activity; REPs; GC MS; H4IIE-luc bioassay; Chemistry; Kemi;

    Sammanfattning : Contaminated soils are a worldwide problem. Polycyclic aromatic hydrocarbons (PAHs) are common contaminants in soil at former industrial areas, especially at old gasworks sites, gas stations and former wood impregnation facilities. LÄS MER

  4. 13. Bioassay analysis of dioxin-like compounds : response interactions and environmental transformation of Ah receptor agonists

    Författare :Helena Olsman; Magnus Engwall; John P. Giesy; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioassay; dioxin-like; Ah receptor; Biology; Biologi; Biology; Biologi;

    Sammanfattning : Dioxin-like compounds mediate their toxicity by binding to the aryl hydrocarbon receptor (AhR) and through this receptor a cascade of biochemical and toxic events are triggered. Mechanism-specific dioxin bioassays utilise the AhR coupled induction of endogenous CYP1A proteins or reporter gene systems for detection of dioxin-like compounds and other AhR ligands. LÄS MER

  5. 14. Role of GLP-1 receptor agonists in endothelial function

    Författare :Özlem Erdogdu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 diabetes;

    Sammanfattning : BACKGROUND: The leading cause of death for patients suffering from type 2 diabetes is macrovascular disease. Endothelial dysfunction is one of the earliest events identified in the pathogenesis of atherosclerosis. Hence, there is a need for finding glucose-lowering agents that cause direct positive effects on vasculature in diabetic patients. LÄS MER

  7. 15. Models and biomarkers of motor and neuropsychiatric complications in Parkinson’s disease

    Författare :Katrine Skovgård; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease Parkinsonism; Dyskinesia; Drug-Induced; Oscillations; Local field potentials; Impulsive-compulsive behaviours; Dopamine agonists; Animal Models; Pharmacology;

    Sammanfattning : Parkinson's disease (PD) is a neurodegenerative disorder characterised by typicalmotor symptoms that are caused by severe dopamine depletion in the cortico-basalganglia network. Parkinsonian motor symptoms are improved by dopaminergicmedications, the most effective being the dopamine precursor L-DOPA. LÄS MER