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Visar resultat 1 - 5 av 134 avhandlingar som matchar ovanstående sökkriterier.

1. 1. SOD1 Aggregation : Relevance of thermodynamic stability

   Författare :Lisa Lang; Mikael Oliveberg; Michele Vendruscolo; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aggregation; misfolding; Superoxide dismutase SOD1 ; Amyotrophic lateral sclerosis ALS ; unfolding; thermodynamic stability; Biochemistry; biokemi;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the upper and lower motor neurons causing muscle atrophy and paralysis followed by death. Aggregates containing superoxide dismutase (SOD1) are found as pathological hallmark in diseased ALS patients. LÄS MER

3. 2. Unravelling protein stability and aggregation

   Författare :Tanja Weiffert; NanoLund: Centre for Nanoscience; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein aggregation; amyloid beta peptide; protein stabilization; split GFP; monellin; secretagogin; ; aggregation kinetics; toxicity; aggregation mechanism; coaggregation;

   Sammanfattning : Proteins are complex macromolecules that are fundamental to all living species. The stability of proteins are governed by non-covalent forces within the protein and between the protein and its surrounding environment. LÄS MER

4. 3. On the molecular mechanisms of the amyloid β-peptide aggregation

   Författare :Kalyani Sanagavarapu; NanoLund: Centre for Nanoscience; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein aggregation; amyloid β-peptide; aggregation kinetics; aggregation mechanism N-terminus; mutations; variants; sequence determinants; ; cross-seeding;

   Sammanfattning : The pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. LÄS MER

5. 4. Isotopes as Mechanism Spies : Nucleophilic Bimolecular Substitution and Monoamine Oxidase B Catalysed Amine Oxidation Probed with Heavy Atom Kinetic Isotope Effects

   Författare :Susanna MacMillar; Olle Matsson; Anita Hussénius; Daniel M. Quinn; Uppsala universitet; []
   Nyckelord :Organic chemistry; nucleophilic bimolecular substitution SN2; kinetic isotope effects; precision conductometry; monoamine oxidase B MAO B; reaction mechanism; carbon 11C 14C kinetic isotope effect; ion pairing triple-ion formation; para-substituted benzyl chlorides; tetrabytylammonium cyanide; Organisk kemi;

   Sammanfattning : This thesis concerns the study of reaction mechanisms by means of kinetic isotope effects (KIEs). Studies of the nucleophilic bimolecular substitution (SN2) reaction had the dual purpose of improving our fundamental understanding of molecular reactivity and assessing the ability of kinetic isotope effects to serve as mechanistic tools. LÄS MER

7. 5. Secondary Nucleation in Amyloid Formation

   Författare :Mattias Törnquist; NanoLund: Centre for Nanoscience; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; amyloid; Ab42; aggregation mechanism; aggregation kinetics; secondary nucleation; Protein misfolding;

   Sammanfattning : Research into Alzheimer's disease is still hampered by a lack of fundamental understanding of the underlying mechanisms. While the aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is highly implicated as a key factor in the disease, the molecular nature of its involvement has proven complex and elusive. LÄS MER