Sökning: "age-related degradation"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden age-related degradation.

  1. 1. Retinal pigment epithelial cells, oxidative stress and lipofuscin : relation to age-related macular degeneration

    Författare :Staffan Sundelin; Stefan Seregard; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : In developed countries, age-related macular degeneration (AMD) is the most common cause of loss of central vision in people over the age of 65. The retinal pigment epithelium (RPE) appears to be the site of early pathological changes in AMD. LÄS MER

  3. 2. Ultimate and Residual Strength Assessment of Ship Structures

    Författare :Artjoms Kuznecovs; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; ship structures; collision; corrosion; residual strength; ultimate strength; age-related degradation; nonlinear FEA; Smith method;

    Sammanfattning : The prevention of ship structural failures and reduction of accident consequences contribute to increased safety at sea and reduced environmental impact. A need for reliable and efficient ship designs facilitates knowledge accumulation and the development of tools for the assessment of hull structural responses to acting loads. LÄS MER

  4. 3. Tipping the scales in cancer : novel mechanisms of inhibiting protein degradation

    Författare :Tatiana A Giovannucci; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein homeostasis (in short, ‘proteostasis’) requires the timely degradation of proteins to retain control on protein quality, amount and function. Two main proteolytic systems, the ubiquitin-proteasome system (UPS) and autophagy, complement each other to fulfill this regulatory role. LÄS MER

  5. 4. Ageing-associated changes of lysosomal compartment : implications on cellular functions

    Författare :Yuri Stroikin; Ulf Brunk; Alexei Terman; Karin Öllinger; Suresh Rattan; Linköpings universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Ageing; Apoptosis; Biological gabarge; Hormesis; Lipofuscin; Lysosome; Pathology; Patologi;

    Sammanfattning : The lysosomal compartment is a major site for intracellular degradation. Lysosomal degradation of the cell’s own constituents, so-called autophagy, not only provides a cell with nutrients, but also removes damaged and potentially dangerous endogenous structures, thus securing intracellular homeostasis. LÄS MER

  7. 5. Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae

    Författare :Sandra Malmgren Hill; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging; protein damage; quality control; metacaspase; aggregates; segregation; vacuole;

    Sammanfattning : The process of aging is defined as a time-dependent decline in cellular functionality, and aging is thought to have evolved as organisms were optimized for reproduction, at the cost of an imperfect repair and maintenance system. As a consequence, different kinds of dysfunctional components and damage accumulate over time. LÄS MER