Sökning: "affinity LC-MS"
Hittade 5 avhandlingar innehållade orden affinity LC-MS.
1. Introducing weak affinity chromatography to drug discovery with focus on fragment screening
Sammanfattning : Fragment-based drug discovery is an emerging process that has gained popularity in recent years. The process starts from small molecules called fragments. One major step in fragment-based drug discovery is fragment screening, which is a strategy to screen libraries of small molecules to find hits. LÄS MER
2. New fractionation tools targeting elusive post-translational modifications
Sammanfattning : Protein phosphorylation is a reversible post-translational modification (PTM)playing a central role in numerous biological events including disease pathogenesis.Thus, the analysis of phosphoproteome is crucial for understandingcellular regulation processes and can facilitate the development of new diagnosticand therapeutic tools. LÄS MER
3. Metabolism of some polychlorinated biphenyl and polybrominated diphenyl ether congeners in the rat
Sammanfattning : For the understanding of the metabolic fate of xenobiotics, in vivo studies are needed. In this thesis the metabolism of CB-28 and CB-77 and BDE-209 in the rat are determined. In addition, pharmacokinetic studies of CB-28 and BDE- 209 are included. The compounds were radiolabelled and their excretion and tissue distribution determined. LÄS MER
4. Studies on O-glycosylation of mucin-type proteins and their binding to antibodies, bacterial toxins and viral receptors
Sammanfattning : Carbohydrates are ubiquitous on the surface of all cells in mammals where they are involved in interactions with the surroundings (extracellular matrix), other cells (including self and non-self) and microbes (bacteria and virus). Carbohydrate-protein interactions in nature are often mediated via multivalent binding where the combined strength of multiple receptor- ligand interactions results in a binding that is highly specific and strong. LÄS MER
5. Piperaquine and Metabolites - Bioanalysis and Pharmacokinetics
Sammanfattning : Antimalarial piperaquine (PQ) is currently used as a partner drug with dihydroartemisinin (DHA), exhibiting high cure rates (>95%) for P. falciparum. Despite its raising usage worldwide with DHA, PQ is synthetically developed outside of big pharma pipelines. LÄS MER