Sökning: "affected sib-pair"
Hittade 5 avhandlingar innehållade orden affected sib-pair.
1. On Power Estimation and Score Predictions in Affected Sib-Pair Linkage Analysis
Sammanfattning : This thesis consists of three papers in statistical genetics, with the emphasis on affected sib-pair linkage analysis. In Paper A, a method to derive the power of linkage analysis in genome scans, using a stepwise approach, is presented. LÄS MER
2. Two-Locus affected sib-pair identity by descent probabilities
Sammanfattning : .... LÄS MER
3. Identifying Risk Genes for Cervical Cancer : Using Affected Sib-Pairs and Case-Control Materials from Sweden
Sammanfattning : Cervical cancer is a multifactorial disease. Infection by oncogenic types of the human papillomavirus (HPV) is the major environmental risk factor and host genetic susceptibility also influences disease development. The aim of this thesis is to identify and analyse risk genes involved in the genetic predisposition to cervical carcinoma. LÄS MER
4. Multiple sclerosis linkage analysis and DNA variation in a complex trait
Sammanfattning : Multiple sclerosis is a life-long disease affecting approximately 11.000 individuals in Sweden today. It is the second most common cause of neurological disability amongst young adults, only outnumbered by traffic accidents. Genetic epidemiological studies indicate that genetic factors contribute to the susceptibility of MS. LÄS MER
5. Linkage and association analysis in multiple sclerosis
Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which is characterized by relapsing or progressive demyelinating plaques in the brain and spinal cord. It is well established that complex genetic factors influence susceptibility to MS. LÄS MER