Sökning: "adult-onset"

Visar resultat 21 - 25 av 36 avhandlingar innehållade ordet adult-onset.

  1. 21. Long-term effects of growth hormone replacement in hypopituitary adults on body composition, bone mass and cardiovascular risk factors

    Författare :Mariam Elbornsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth hormone; growth hormone deficiency; growth hormone replacement; bone mineral density; body composition; muscle strength; elderly; cardiovascular risk factors; pituitary irradiation;

    Sammanfattning : Growth hormone (GH) deficient (GHD) adults have decreased bone mass and muscle strength, impaired body composition, disturbed serum lipid pattern and increased morbidity and mortality in cardiovascular and cerebrovascular diseases. GH replacement normalizes most of these aberrations within the first year of treatment. LÄS MER

  3. 22. Spinal and bulbar muscular atrophy : new insights into the disease mechanism and prospects for pharmacological therapy

    Författare :Laura C Bott; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Expansion of a polyglutamine-encoding trinucleotide CAG repeat in the androgen receptor (AR) gene causes spinal and bulbar muscular atrophy (SBMA, or Kennedy’s disease). SBMA is an adult-onset disease characterized by progressive muscle weakness and atrophy due to the degeneration of lower motor neurons in the brainstem and spinal cord. LÄS MER

  4. 23. Alcohol, tobacco and the risk of LADA-latent autoimmune diabetes in adults

    Författare :Bahareh Rasouli; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes is a common and increasing public health problem. Knowledge of risk factors is a prerequisite for efficient prevention; such knowledge is extensive for type 2 diabetes but limited for autoimmune forms of diabetes. LÄS MER

  5. 24. Genetic predisposition to immune cell malfunction and inflammation

    Författare :Lamberto J Torralba-Raga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our genome contains all the instructions to control the synthesis of proteins, the development of cells and the interaction between body systems. We are armed with an immune system, made up of cells, chemical compounds and physical barriers, that protects us from invading pathogens. LÄS MER

  7. 25. Metabolomics studies of ALS : a multivariate search for clues about a devastating disease

    Författare :Anna Wuolikainen; Peter M Andersen; Henrik Antti; Stefan L Marklund; Thomas Moritz; Thomas Hankemeier; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyotrophic lateral sclerosis ALS ; motor neuron disease; Lou Gehrig’s disease; human disease; CSF; biomarkers; metabolomics; metabonomics; chemometrics; design of experiments; multivariate analysis.; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS), also known as Charcot’s disease, motor neuron disease (MND) and Lou Gehrig’s disease, is a deadly, adult-onset neurodegenerative disorder characterized by progressive loss of upper and lower motor neurons, resulting in evolving paresis of the linked muscles. ALS is defined by classical features of the disease, but may present as a wide spectrum of phenotypes. LÄS MER