Sökning: "adjuvants"

Visar resultat 21 - 25 av 69 avhandlingar innehållade ordet adjuvants.

  1. 21. The role of adjuvant-induced innate immune activation in shaping vaccine responses

    Författare :Elizabeth A Thompson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Adjuvants are components added to non-live vaccine formulations to enhance the effect of the vaccine by alerting the immune system to initiate a response against the vaccine. Powerful new adjuvants will be critical for the development of next generation vaccines to diseases such as tuberculosis, HIV-1/AIDS, malaria, and therapeutic cancer vaccines. LÄS MER

  3. 22. Studies on immunological mechanisms of induced arthritis in the rat

    Författare :Lena Svelander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Arthritis; autoimmunity; adjuvant; incomplete Freund s adjuvant; squalene; CpG;

    Sammanfattning : Experimental arthritis induced with adjuvants shares many features with the human autoimmune disorder rheumatoid arthritis (RA). The use of arthritis models is therefore a relevant approach in the search for pathogenic mechanisms in human disease. LÄS MER

  4. 23. Innate immune responses in vivo after antigen administration : implications for vaccine development

    Författare :Frank Liang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inducing high magnitude of antibodies with epitope breadth over prolonged periods of time is likely a prerequisite to prevent several of the world’s most serious infectious diseases such as HIV-1, malaria and tuberculosis for which there are no vaccines yet. A much better understanding of the innate immune mechanisms that are critical for inducing strong responses to vaccination is therefore essential. LÄS MER

  5. 24. Immune mechanisms that determine the quality of antibody responses to vaccines

    Författare :Gustaf Lindgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Effective vaccines for many dangerous infectious diseases are still lacking. An improved understanding of the mechanisms that determine the quality of vaccine responses is essential to guide future attempts to design effective vaccines. LÄS MER

  7. 25. Innate immune responses to a saponin adjuvant in the pig : application of gene expression profiling

    Författare :Viktor Ahlberg; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Vaccination is one of the most powerful ways to prevent infectious diseases. Successful vaccines produce a long-term immunity including effector T and B lymphocytes. In this context, adjuvants have a key role in vaccines by stimulating the innate immunity and thereby enhancing and shaping the subsequent adaptive immune response. LÄS MER