Sökning: "adipocyte differentiation-related protein"
Hittade 3 avhandlingar innehållade orden adipocyte differentiation-related protein.
1. Lipid storage and secretion. Studies on VLDL assembly and foam cell formation
Sammanfattning : This thesis deals with formation of two factors of upmost importance for the development of atherosclerosis: the triglyceride rich very low density lipoproteins 1 (VLDL1) and the lipid loaded macrophages ("foam cells"- characteristic features of the atherosclerotic lesion). Both these processes depend on the cellular accumulation of lipids. LÄS MER
2. Studies on the assembly of cytosolic lipid droplets. Importance of Phospholipase D and ADRP in the process
Sammanfattning : The storage of triglycerides in cells such as adipocytes, liver or muscle cells is of great physiological importance, having implications for our most important metabolic diseases such as obesity, the metabolic syndrome and type II diabetes. A common denominator in these diseases is the insulin resistance, which is also highly related to the production of atherogenic lipoproteins and the development of atherosclerosis and consequently cardio-vascular diseases. LÄS MER
3. LXR regulation of hepatic gene expression and pituitary dependent hormones
Sammanfattning : The liver X receptors (LXRs) are ligand activated transcription factors involved in the regulation of metabolic genes. LXRs are considered potential drug targets to treat metabolic disorders, however, unwanted side effects, as revealed from rodent studies, include increased lipogenesis in the liver and increased plasma triglyceride levels. LÄS MER