Sökning: "adenovirus"

Visar resultat 11 - 15 av 143 avhandlingar innehållade ordet adenovirus.

  1. 11. Nuclear Organization of Gene Expression in Adenovirus Infected Cells

    Författare :Anders Aspegren; Lars Wieslander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Adenovirus; mRNA; transport; IGCs; E434kDa; E1B55kDa; NES; snRNP; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Adenovirus infected cells provide a good model system for studying nuclear organization during RNA production and transport. This thesis is focused on the dynamic organization of splicing factors during the late phase of Adenovirus infection in HeLa cells, the nuclear localization of viral RNA, and the pathway used for viral RNA transport to the cytoplasm. LÄS MER

  3. 12. The Multifunctional Nature of the Adenovirus L4-22K Protein

    Författare :Susan Lan; Göran Akusjärvi; Per Elias; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-22K; MLP; RNA; transcription; splicing; adenovirus;

    Sammanfattning : The adenovirus major late transcription unit (MLTU) encodes for most of the mRNAs that are translated into the structural proteins of the virus capsid. Transcription from the MLTU is directed by the major late promoter (MLP), which is highly activated during the late phase of infection. LÄS MER

  4. 13. Retargeting of adenovirus vectors. Viral ligands and cellular receptors

    Författare :Petra Henning; Göteborgs universitet; []
    Nyckelord :Adenovirus; vector; gene therapy; gene transfer; retargeting; detargeting; tumor targeting; fiber; pIX; affibody molecule; single chain antibody;

    Sammanfattning : Gene therapy is one of the newest technologies attempted to treat human cancer. Progress in the field has however been hampered by the lack of efficient and safe vectors. Ideal vectors should specifically transduce desired cells in vivo. This thesis is devoted to the development and evaluation of retargeted adenovirus type 5 (Ad5) vectors. LÄS MER

  5. 14. Early host cell interactions and antivirals against ocular adenoviruses

    Författare :Rickard Storm; Niklas Arnberg; Saw See Hong; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; Virus host interactions; Antivirals; Sialic acid; Integrins; Epidemic keratoconjuntivitis;

    Sammanfattning : Viruses are common causative agents of ocular infection among humans. Epidemic keratoconjuntivitis (EKC) is a severe and contagious ocular disease with reported outbreaks worldwide. It is estimated that this disease affects 20-40 million individuals every year, which leads to huge socioeconomic costs for the affected countries. LÄS MER

  7. 15. Global Profiling of Host Cell Gene Expression During Adenovirus Infection

    Författare :Fredrik Granberg; Hongxing Zhao; Ulf Pettersson; Richard Roberts; Uppsala universitet; []
    Nyckelord :Genetic engineering; Adenovirus; Microarray; Gene expression; Host-virus interaction; Genteknik;

    Sammanfattning : To investigate mechanisms involved in virus-host interactions, global changes in host gene expression were examined during infection with adenovirus type 2 (Ad2) using cDNA microarray technology. In paper I and II, transcriptional changes in HeLa cells were investigated during the early and late phase of infection, respectively. LÄS MER