Sökning: "adenosine deaminase"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden adenosine deaminase.

1. 1. Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects

   Författare :Maria Torvinen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine; adenosine deaminase; A; receptor; A2A receptor; cell line; coimmunoprecipitation; confocal microscopy; dopamine; D1 receptor; D2 receptor; D3 receptor; heteromerization; internalisation; radioligand binding;

   Sammanfattning : The dopamine receptors have been shown to be involved in a variety of higher brain functions, such as motor control, cognition and affective states. Agonist and antagonists of dopamine receptors are widely used to treat disorders such as Parkinson's disease and schizophrenia, respectively. LÄS MER

3. 2. Metabolic roles of adenosine : studies using genetically modified mice and transfected cells

   Författare :Stina Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine; A1 receptor; adipocyte; pancreas; skeletal muscle; GHSR1a; caffeine; metabolism and knock out mouse;

   Sammanfattning : The aim of this thesis was to further investigate the metabolic roles of adenosine. The endogenous nucleoside adenosine acts by binding to the four adenosine receptors, A1R, A2AR, A2BR and A3R. The A1R is the adenosine receptor that has been proposed to be the one most involved in metabolism. LÄS MER

4. 3. Adenosine receptor signaling and the activation of mitogen-activated protein kinases

   Författare :Gunnar Schulte; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The nucleoside adenosine is present in all cells and body fluids of all living organisms; its production, both intracellularly and extracellularly, is tightly coupled to energy consumption resulting in increasing extracellular adenosine levels with increased energy consumption. Adenosine is metabolized by adenosine deaminase and adenosine kinase. LÄS MER

5. 4. Adenosine action on platelets : pharmacological and functional studies in human platelets in vitro

   Författare :Ulla Söderbäck; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :adenosine; adenosine analogs; methylxanthines; cyclic AMP; ADP; dipyridamole; platelet-rich plasma; whole blood aggregatron; human. Ulla SöderbäckAdenosine action on platelets. Pharmacological and functional studies in human pl;

   Sammanfattning : The endogenous purine adenosine (ADO) is known to inhibit platelet aggregation in vitro through increased platelet levels of cyclic AMP. This effect is ADO-A2-receptor-mediated through stimulation of membrane adenylyl cyclase. LÄS MER

7. 5. Molecular dynamics of protein-nucleic acid complexes

   Författare :Katarina Hart; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Nucleic acids are essential molecules when it comes to replication, transcription and translation of the genetic information and nearly all functions of nucleic acids are carried out in complex with proteins. The proteins need to be able to discriminate between different sites on the nucleic acids for correct binding. LÄS MER