Sökning: "acute promyelocytic leukaemia"

Hittade 3 avhandlingar innehållade orden acute promyelocytic leukaemia.

  1. 1. Improving prognostication and treatment choices for patients with AML

    Författare :Albin Österroos; Sören Lehmann; Marc H G P Raaijmakers; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukaemia; Acute promyelocytic leukaemia; Prognostication; Personalised medicine; Risk stratification; Real-world data; Next-generation sequencing; Azacitidine; Venetoclax; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The treatment landscape of the aggressive haematological malignancy acute myeloid leukaemia (AML) has expanded but the prognosis is still unsatisfactory poor. Here, we aimed at improving prognostication and treatment choices in AML by addressing current clinical obstacles to successful AML treatment. LÄS MER

  3. 2. Regulation of tissue factor expression in myeloid and monocytic leukaemia cells

    Författare :Taavo Tenno; Uppsala universitet; []
    Nyckelord :Medical sciences; tissue factor; blood coagulation; monocytes; cell differentiation; retinoic acid; vitamin D3; acute promyelocytic leukaemia; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Clinical Chemistry; klinisk kemi;

    Sammanfattning : Tissue factor (TF) is a transmembrane glycoprotein that initiates the blood coagulation cascade and is also involved in cell migration, tumour metastasis and angiogenesis. Pathologic expression of tissue factor by monocytes contributes to several thrombotic complications like acute coronary artery disease and disseminated intravascular coagulation. LÄS MER

  4. 3. Effects of arsenic trioxide and hypoxia in multidrug-resistant neuroblastoma

    Författare :Jenny Karlsson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; neuroblastoma; multidrug resistance; hypoxia; glucose-deficiency; cell death; Bax; Apoptosis; arsenic trioxide;

    Sammanfattning : Neuroblastoma is a childhood tumour derived from the sympathetic nervous system. Although most children with neuroblastoma initially respond to treatment, approximately 50% of these patients relapse with multidrug-resistant tumours. Arsenic trioxide (As2O3) has been used for centuries to treat different clinical disorders including malignancies. LÄS MER