Sökning: "acute phase proteins"

Visar resultat 21 - 25 av 75 avhandlingar innehållade orden acute phase proteins.

  1. 21. Novel endogenous mechanisms of complement regulation - A delicate balance

    Författare :Andreas Holmér; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; short leucine rich glycoprotein; factor H; C1q; age-related macular degeneration; C4b-binding protein; prion disease; prion protein; Complement regulation; C-reactive protein;

    Sammanfattning : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. LÄS MER

  3. 22. Management of thoracoabdominal aortic aneurysms and dissections : with emphasis on spinal cord protection in aneurysm repair and non-surgical treatment of type-B dissection

    Författare :Anders Winnerkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aortic cross-clamping; cerebrospinal fluid drainage; GFAp; NFL; retrograde venous spinal cord perfusion; somatosensory evoked potentials; S100B; thoracoabdominal aortic aneurysm; type B aortic dissection.;

    Sammanfattning : Thoraco-abdominal aortic aneurysms and dissections are two very serious disease processes which entail a high risk of vessel rupture and death. Their specific treatment strategies have several similarities which have formed a base for this thesis. LÄS MER

  4. 23. Inflammatory status in adolescents : the impact of health determinants such as overweight and fitness

    Författare :Julia Wärnberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adolescence; low-grade inflammation; CRP; ceruloplasmin; C3; C4; overweight; cardiorespiratory fitness.;

    Sammanfattning : Overweight prevalences are rising among youth and the prevention of associated chronic diseases is priority concern in public health. Inflammatory processes are involved in the pathogenesis of cardiovascular diseases and may also play an important initiating role in the development of the cardiovascular lesion. LÄS MER

  5. 24. On inflammation and cardiovascular disease in patients with rheumatoid arthritis

    Författare :Solveig Wållberg Jonsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; mortality; cardiovascular disease; ischemic heart disease; inflammation; lipids; Lp a ; haemostasis; fibrinolysis; atherogenesis; thrombogenesis;

    Sammanfattning : Patients with rheumatoid arthritis (RA) have a shorter life span than the general population. An increased death due to cardiovascular disease (CVD) has been reported. RA is characterized by synovitis and joint destruction accompanied by an acute phase reaction and systemic features. LÄS MER

  7. 25. Molecular markers for prediction of response and progression free survival to novel therapies in cutaneous malignant melanoma

    Författare :Fernanda Costa Svedman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drugs inhibiting the MAPK-pathway (MAPKi) and immune checkpoint inhibitors (ICI) have changed the clinical outcome of metastatic cutaneous malignant melanoma (CMM) in a significant way. Nonetheless, many patients have primary resistance or develop acquired resistance to these therapies within a relatively short period of time. LÄS MER