Sökning: "activity-dependent release"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden activity-dependent release.

  1. 1. Roles of SNAP-25 isoforms in activity-dependent long-term synaptic plasticity

    Författare :Muhammad Irfan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : SNARE proteins, SNAP-25, syntaxin 1A and VAMP2 constitute the functional units which join together to form the core SNARE complex. The SNARE complex carries out the vital function of membrane fusion of intracellular vesicles with plasma membranes, leading to the release of neurotransmitters in brain neuronal circuits and of hormones in endocrine glands. LÄS MER

  3. 2. Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides

    Författare :Andreas Toft Sörensen; Experimentell Epilepsi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTP; synaptic plasticity; synaptic transmission; electrophysiology; Y5 receptor; Y2 receptor; neuropeptide Y NPY ; hippocampus; gene therapy; epilepsy; memory; activity-dependent release; volume transmission;

    Sammanfattning : Intractable seizures and lack of effective antiepileptic drugs (AED) are severe and common conditions affecting many patients with epilepsy. Thus, there is an urgent need to develop new therapies in epilepsy. The search for novel treatments has identified several neuropeptide systems as potential targets for future therapeutic interventions. LÄS MER

  4. 3. Investigation of Exocytosis for a New Paradigm of Plasticity in Biological Systems Using Electrochemistry and Mass Spectrometry Imaging

    Författare :Chaoyi Gu; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Cellular communication is a vital process and serves as the basis for complex brain functions in multicellular organisms. The majority of cellular communication is achieved via the release of specific signaling molecules, transmitters and modulators, via a process termed exocytosis. LÄS MER

  5. 4. Changes in neuronal properties induced by neurotropic infections

    Författare :Björn Owe-Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nervous system can be the target for various bacterial and viral infectious agents. Certain bacterial toxins have been found to impair specific proteins, such as proteins involved in transmitter release and in the regulation of the cytoskeleton. LÄS MER

  7. 5. Astrocyte-mediated short-term synaptic depression

    Författare :My Andersson; Göteborgs universitet; []
    Nyckelord :glutamate; glia; plasticity; synapse; hippocampus;

    Sammanfattning : Short-term synaptic plasticity, the activity-dependent regulation of synaptic efficacy that occurs in the timeframe of milliseconds to seconds, is a fundamental property of the synapse, mostly attributed to changes in release probability. These changes are commonly ascribed to intrinsic mechanisms in the presynaptic terminal and to different transmitters acting on the presynaptic terminal. LÄS MER