Sökning: "activity quantification"

Visar resultat 6 - 10 av 137 avhandlingar innehållade orden activity quantification.

  1. 6. Creating Ultrafast Biosensors for Neuroscience

    Författare :Yuanmo Wang; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; quantification; glucose; choline oxidase; gold nanoparticles; enzyme monolayer; enzymatic activity; Biosensor; adsorption; brain slice; enzyme stability; acetylcholine esterase; artificial cell; exocytosis; glucose oxidase; deformation; glutamate; glutamate oxidase; acetylcholine; amperometry;

    Sammanfattning : Neuronal communication is the basis for all our brain function and relies on regulated exocytosis, a cell function that involves release of quantal amounts of neurotransmitters into the gap space between interconnected neurons to serve as chemical signals. To study exocytosis, which is a fast process that occurs on the timescale of sub-milliseconds to milliseconds, a toolbox of analytical methods has been developed where the electrochemical based techniques offer quantitative and sufficient high temporal recording speed. LÄS MER

  3. 7. Development of Ultra-fast Biosensors for Detection of Non-electroactive Neurotransmitters

    Författare :Yuanmo Wang; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; artificial cell; quantification; stability; deformation; dynamic light scattering; adsorption; amperometry; nanoparticle tracking analysis; enzyme monolayer; glucose oxidase; exocytosis; choline oxidase; acetylcholine; enzymatic activity; acetylcholine esterase; gold nanoparticles; Biosensor;

    Sammanfattning : During neuronal communication neurotransmitters are released through the process exocytosis that occurs on the time scale of sub-milliseconds to milliseconds. Neuronal activity by neurotransmitters that are non-electroactive cannot easily be monitored due to limitations in the temporal resolutions of the sensor probes for these analytes. LÄS MER

  4. 8. Quantification of pulmonary scintigraphy

    Författare :Jiahua Xu; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Emphysema; Inhomogeneity; Perfusion; scintigraphy; SPECT; 99mTc-Technegas; Ventilation; V Q;

    Sammanfattning : Modern nuclear medicine techniques, such as SPECT (single photon emission computed tomography), enable quantification and localisation of lung function in small lung elements, but appropriate methods are not yet available. The aim of the present project was therefore to develop and evaluate methods for mapping lung function in planar scintigrams and in SPECT. LÄS MER

  5. 9. Imaging and Quantification of Brain Serotonergic Activity using PET

    Författare :Pinelopi Lundquist; Margareta Hammarlund-Udenaes; Per Hartvig; Gunnar Blomquist; Paul Cumming; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Brain serotonin; Neurotransmitter release; Neurotransmitter synthesis; Positron emission tomography; Tracer validation; Tracer modelling; Farmakokinetik Farmakoterapi;

    Sammanfattning : This thesis investigates the potential of using positron emission tomography (PET) to study the biosynthesis and release of serotonin (5HT) at the brain serotonergic neuron. As PET requires probe compounds with specific attributes to enable imaging and quantification of biological processes, emphasis was placed on the evaluation of these attributes. LÄS MER

  7. 10. Internal Dosimetry Development and Evaluation of Methods and Models

    Författare :Lena M Jönsson; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; crypt cells; intestine; radionuclide; scintillation camera; sestamibi; activity quantification; conjugate view method; Monte Carlo simulation; internal dosimetry; Nuclear medicine; radiobiology; Nukleärmedicin; radiobiologi; medicinsk instrumentering; radiologi;

    Sammanfattning : Radionuclide therapy requires patient-specific planning of the absorbed dose to target volumes, in most cases tumours, in order to achieve an expected biological effect, taking into account that the absorbed doses to normal organs and tissues should be kept as low as reasonably achievable. Therefore, the calculation of absorbed doses has to be as accurate as possible. LÄS MER