Sökning: "activity linking"

Visar resultat 6 - 10 av 107 avhandlingar innehållade orden activity linking.

  1. 6. Spatial variability linking carbon resource heterogeneity and microorganisms; causes and consequences

    Författare :Niklas Törneman; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bakteriologi; virologi; mykologi; Environmental chemistry; Miljökemi; Mikrobiologi; mycology; virology; bacteriology; Microbiology; Ekologi; Ecology; Geostatistics; Microbial activity; Soil organic carbon; Microbial diversity; Biodegradation; Bioremediation; PAH; Spatial patterns;

    Sammanfattning : Organic carbon and bacteria have a high variability at different scales in the soil, and organic carbon may be a limiting factor for growth of soil bacteria. Thus, it can be expected that these co-vary at different scales in the soil. LÄS MER

  3. 7. Pathways linking atherosclerosis to aortic stenosis

    Författare :Oscar Plunde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular disease is the most common cause of death world-wide where atherosclerosis is the main culprit and aortic valve disease accounts about two percent of all CVD deaths. Atherosclerosis is a lipid and inflammation driven disease that share many features with aortic valve stenosis (AVS). LÄS MER

  4. 8. Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors

    Författare :Tina Seifert; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sirtuin; SIRT2; Inhibitors; Chroman-4-ones; Chromones; Benzothiadiazine-1; 1-dioxides; Saccharin; Scaffold; Structure-activity relationship; Antiproliferative properties; Binding site; Homology modeling; Photoaffinity labeling; Diazirine; Mass spectrometry;

    Sammanfattning : Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell proliferation, apoptosis and metabolism. They are proposed to be involved in the pathogenesis of e.g. LÄS MER

  5. 9. Linking transcription to DNA replication in mammalian mitochondria

    Författare :Yonghong Shi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Most of the adenosine phosphate (ATP) used to drive cellular processes is produced through oxidative phosphorylation (OXPHOS). At the heart of this process is the electron transport chain, which contains a number of protein complexes located in the inner membrane of mitochondria. LÄS MER

  7. 10. Health economics and its measures in rheumatoid arthritis

    Författare :Johan Karlsson; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cost-utility analysis; Cost-of-illness; Quality of life; EuroQol 5-Dimensions; Antirheumatic agents; TNF inhibition; Outcome assessment; Disease activity; Disability; Health economics; Rheumatoid arthritis;

    Sammanfattning : Objectives: To study: (I) the impact on cost-utility analyses of applying different national EuroQol 5-Dimensions (EQ-5D) preference sets; (II and III) whether, in methotrexate-refractory, early rheumatoid arthritis (RA), the addition of infliximab results in superior health-related quality of life (HRQoL) and may be considered cost-effective, as compared to adding sulfasalazine and hydroxychloroquine; (IV) how costs relate to disability (measured by the health-assessment questionnaire, HAQ), disease activity (28-joint disease activity score, DAS28) and HRQoL (EQ-5D) in RA. Methods: In the observational SSATG register, one-year quality-adjusted life-year (QALY) accumulation of two interventions was compared according to the UK, US, or Danish EQ-5D preference sets. LÄS MER