Sökning: "activity linking"

Visar resultat 16 - 20 av 107 avhandlingar innehållade orden activity linking.

  1. 16. Human immunodeficiency virus type 1 proteinase : regulation of function and catalytic activity

    Författare :Laura Goobar-Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-l proteinase activity is a prerequisite for viral replication, and one of the main targets for anti-HlV therapy. Although potent proteinase inhibitors are currently being approved for treatment of AIDS patients, these drugs are unlikely to provide treatment which can give patients a life of normal quality and duration. LÄS MER

  3. 17. Constraining the timing of veins, faults and fractures in crystalline rocks by in situ Rb-Sr geochronology

    Författare :Mikael Tillberg; Henrik Drake; Mats E. Åström; Thomas Zack; Johan Hogmalm; Bjarne Almqvist; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; geochronology; brittle deformation; crustal fluids; mineral precipitation; ancient microbial activity; Precambrian craton; Scandinavia; Natural Science; Naturvetenskap;

    Sammanfattning : Precambrian cratons are continent cores archiving the oldest crustal histories on Earth. The crystalline basement of cratons is typically characterized by complex arrays of multiple fracture and fault generations hosting minerals formed by fluids flowing through fracture networks. LÄS MER

  4. 18. Porins of Borrelia burgdorferi

    Författare :Marija Pinne; Sven Bergström; Magnus Höök; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lyme disease; P13; paralog; P66; channel-forming activity; porin; Medical microbiology; Medicinsk mikrobiologi;

    Sammanfattning : Borrelia burgdorferi is a pathogenic spirochete which cycles between its arthropod vector and vertebrate host. If transmitted to humans, B. burgdorferi causes Lyme disease, an infection which can impair different organs, such as the skin, joints, nervous system and heart. LÄS MER

  5. 19. Beta-arrestins in cancer : linking pro-tumorigenic extracellular activated signaling with the tumor suppressor p53 pathway

    Författare :Naida Suleymanova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The IGF-1R is an important player in cancer development that maintains the malignant phenotype by inducing cell proliferation, survival, transformation, motility and invasiveness. Activation of IGF-R results in its Mdm2-dependent ubiquitination and degradation followed by MAPK signaling. LÄS MER

  7. 20. Teaching in an age of complexity : exploring academic change and development in higher education

    Författare :Claire Englund; Anders D. Olofsson; Linda Price; Shirley Booth; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Higher Education; Academic Development; Educational Technology; Conceptions of Teaching and Learning; Cultural-Historical Activity Theory; Change and Development; pedagogik; Education;

    Sammanfattning : Higher education (HE) has expanded and diversified at an unprecedented rate over the last two decades in response to a rapidly changing educational and political climate. Change and development are omnipresent, a constant part of university teachers’ sociocultural and organisational practice at multiple levels; the micro-level, the meso-level and the macro-level Against this background, the aim of this thesis is to gain a deeper understanding of the factors that influence academic change. LÄS MER