Sökning: "active site model"

Visar resultat 1 - 5 av 232 avhandlingar innehållade orden active site model.

1. 1. Synthetic [FeFe] Hydrogenase Active Site Model Complexes

   Författare :Lennart Schwartz; Sascha Ott; Marcetta Y. Darensbourg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hydrogenase mimic; proton reduction; bioinorganic chemistry; diiron hexacarbonyl complexes; artifical photosynthesis; hydrogen; Organic chemistry; Organisk kemi;

   Sammanfattning : [FeFe]-Hydrogenases (H2ases) are metalloenzymes that can catalyze the reversible reduction of protons to molecular hydrogen as part of the metabolism of certain cyanobacteria and green algae. Due to the low availability of the enzyme, synthetic complexes that mimic the natural active site in structure, function and activity are highly sought after. LÄS MER

3. 2. Natural Products as Leads for Pharmaceutically Active Compounds

   Författare :Pia Kahnberg; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; scaffold hopping; Catalyst; anxiety; benzodiazepine site; GABAA receptor; pharmacophore model; flavones; SAR; antifungal activity; Complex I; pterulone; Organic chemistry; Organisk kemi; Biochemical technology; Biokemisk teknik;

   Sammanfattning : In the search for new pharmaceutically active compounds, it is recognized that Nature produces structurally different compounds in a great variety. By having the compounds or extracts tested in defined systems, new drugs or more often leads (a compound that has an interesting but moderate activity) can be found. LÄS MER

4. 3. Mimicking the Outer Coordination Sphere in [FeFe]-Hydrogenase Active Site Models : From Extended Ligand Design to Metal-Organic Frameworks

   Författare :Sonja Pullen; Sascha Ott; Patrick L. Holland; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; [FeFe]-hydrogenases; outer coordination sphere; model complexes; biomimetic catalysis; artificial photosynthesis; metal-organic frameworks;

   Sammanfattning : Biomimetic catalysis is an important research field, as a better understanding of nature´s powerful toolbox for the conversion of molecules can lead to technological progress. [FeFe]-hydrogenases are very efficient catalysts for hydrogen production. These enzymes play a crucial role in the metabolism of green algae and certain cyanobacteria. LÄS MER

5. 4. On the Application of Surface Wave Surveys for Seismic Site Response Evaluation

   Författare :Edwin Obando; Teknisk geologi; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Surface wave; MASW; seismic site response; ground motion; seismic transfer functions; shear wave velocity; site amplification; walk-away; near-field effect; dispersion curve.;

   Sammanfattning : In sites where earthquakes occur, the use of surface wave methods represents a convenient and effective procedure for soil characterization. In particular, Multichannel Analysis of Surface Wave (MASW) has become a popular tool in many seismic micro-zoning projects. LÄS MER

7. 5. Investigation of RNase P active site residues and catalytic domain interaction

   Författare :Guanzhong Mao; Leif Kirsebom; Roland Hartmann; Britt-marie Sjöberg; Anders Byström; Anthony Forster; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNase P; Ribozyme; PRORP; Induced fit model; RNase P-pre-tRNA interaction; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : RNase P is an essential endoribonuclease responsible for the maturation of the tRNA 5’end. The RNase P family encompasses the ribozyme based, RNase P RNP, and proteinaceous RNase P (PRORP). The ribozyme based RNase P is widely distributed in most species while PRORP has so far mainly been found in some eukaryotic cells. LÄS MER