Sökning: "active metabolite"

Visar resultat 1 - 5 av 111 avhandlingar innehållade orden active metabolite.

  1. 1. Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

    Författare :Martin H Johansson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; Organisk kemi; Organic chemistry; enzyme; mycelium; intramolecular Diels-Alder reaction; Diels-Alderase; asymmetric synthesis; biosynthesis; total synthesis; STAT3 inhibition; galiellalactone; fungal metabolite;

    Sammanfattning : Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. LÄS MER

  3. 2. SARs for the Antiparasitic Plant metabolite Pulchrol

    Författare :Paola Terrazas Villarroel; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pulchrol; pulchral; SARs; antiparasitic; Leishmania braziliensis; Leishmania amazonensis; Trypanozoma cruzi; Bourreria pulchra; Leishmaniasis; Chagas disease; Synthesis; Pharmacophore; ADMET;

    Sammanfattning : Pulchrol, a natural compound isolated from the roots of the vegetal specie Bourreria pulchra has been shown to possess potential antiparasitic activity toward Trypanosomatids, particularly against Trypanosoma cruzi, which causes the Chagas disease; and moderately against Leishmania species, responsible for Leishmaniasis. In this investigation, several pulchrol analogues were prepared and assayed toward T. LÄS MER

  4. 3. Natural Products as Leads for Pharmaceutically Active Compounds

    Författare :Pia Kahnberg; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; scaffold hopping; Catalyst; anxiety; benzodiazepine site; GABAA receptor; pharmacophore model; flavones; SAR; antifungal activity; Complex I; pterulone; Organic chemistry; Organisk kemi; Biochemical technology; Biokemisk teknik;

    Sammanfattning : In the search for new pharmaceutically active compounds, it is recognized that Nature produces structurally different compounds in a great variety. By having the compounds or extracts tested in defined systems, new drugs or more often leads (a compound that has an interesting but moderate activity) can be found. LÄS MER

  5. 4. Developmental Aspects of Drug Transport Across the Blood-Brain Barrier

    Författare :Jörgen Bengtsson; Margareta Hammarlund-Udenaes; Ann-Cathrin Engwall; Sven Björkman; Elizabeth C.M. de Lange; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; development; active transport; tight junction proteins; microdialysis; recovery; morphine; nitrofurantoin; Bcrp; microarray; real-time PCR; in vitro; in vivo; LC-MS MS; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : The developmental aspect of drug transport across the blood-brain barrier (BBB) was investigated. Microdialysis was used to study unbound morphine BBB transport at different ages in sheep. An in vitro study was performed to find differentially expressed genes in brain capillary-rich fractions of the brain in rats of different ages. LÄS MER

  7. 5. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

    Författare :Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. LÄS MER