Sökning: "action net"

Visar resultat 21 - 25 av 678 avhandlingar innehållade orden action net.

  1. 21. Mode of action of asenapine vs. other antipsychotic drugs : an experimental analysis

    Författare :Olivia Frånberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Antipsychotic drugs (APDs) are used in the treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder. Generally, the so-called atypical APDs, such as clozapine, may in contrast to typical APDs improve not only positive, but also negative symptoms and some aspects of cognitive impairment associated with schizophrenia. LÄS MER

  3. 22. On the mechanisms of action of atypical antipsychotic drugs : an experimental study

    Författare :Peter Hertel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :antipsychotic drugs; dopamine; serotonin; medial prefrontal cortex; dorsal raphe nucleus; risperidone; clozapine; idazoxan; [alpha]2 adrenoceptors; conditioned avoidance; catalepsy;

    Sammanfattning : A majority of schizophrenic patients respond to classical neuroleptic drugs which are believed to act largely via blockade of dopamine (DA) D2 receptors in limbic structures. However, a significant proportion do not respond to conventional D2 receptor blocking drugs or show a rather incomplete therapeutic effect, particularly on negative and cognitive symptoms. LÄS MER

  4. 23. Adenosine action on platelets : pharmacological and functional studies in human platelets in vitro

    Författare :Ulla Söderbäck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adenosine; adenosine analogs; methylxanthines; cyclic AMP; ADP; dipyridamole; platelet-rich plasma; whole blood aggregatron; human. Ulla SöderbäckAdenosine action on platelets. Pharmacological and functional studies in human pl;

    Sammanfattning : The endogenous purine adenosine (ADO) is known to inhibit platelet aggregation in vitro through increased platelet levels of cyclic AMP. This effect is ADO-A2-receptor-mediated through stimulation of membrane adenylyl cyclase. LÄS MER

  5. 24. Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis

    Författare :Anca Irinel Catrina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rheumatoid arthritis; TNF antagonists; cytokines; macrophages; matrix metalloproteinases; osteoprotegerin; RANKL; apoptosis;

    Sammanfattning : Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by progressive bone destruction that leads to joint deformity and physical disability. Even though several therapeutic drugs are available, none have emerged as an ideal RA treatment that delays joint destruction and halts disease progression. LÄS MER

  7. 25. PET studies on the mechanisms of action of antidepressant and antipsychotic drugs

    Författare :Kai-Chun Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Positron emission tomography (PET) is a non-invasive molecular imaging technique suitable for examination of neurochemical biomarkers in the living brain. Among these applications, PET studies are used to facilitate the development of novel psychotropic drugs. LÄS MER