Sökning: "acid dissociation constant"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden acid dissociation constant.

1. 1. Studies of α-D-isosaccharinic Acid – Acid dissociation constant and structural conformations

   Författare :Stefan Ekberg; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; α-D-isosaccharinate; nuclear repository; α-D-isosaccharinic acid; potentiometric titration; equilibrium; acid dissociation constant; nuclear waste; stability constant; ion chromatography; α-D-isosaccharino-1; 4-lactone;

   Sammanfattning : .... LÄS MER

3. 2. Statistical Mechanical Studies of Titrating Polyelectrolytes

   Författare :Magnus Ullner; Kemiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; integral equation theory; variational calculations; Monte Carlo simulations; end-to-end separation; apparent dissociation constant; titrating polyelectrolytes; electrostatic interactions; Physical chemistry; Fysikalisk kemi;

   Sammanfattning : Different models and statistical mechanical approximations for titrating polyelectrolytes are studied and the results compared with Monte Carlo simulations and experimental data. Three types of models have been used in the simulations: i) rigid structures and freely jointed chains with ii) rigid bonds and iii) flexible, harmonic bonds. LÄS MER

4. 3. Amino acid transport and receptor binding properties in neuropsychiatric disorders using the fibroblast cell model

   Författare :Jessica Johansson; Nikolaos Venizelos; Lars Oreland; Örebro universitet; []
   Nyckelord :Fibroblasts; Bipolar disorder; ADHD; Tyrosine; Tryptophan; Alanine; Transport; mAChRs; Biomedicin; Biomedicine;

   Sammanfattning : Altered transport of the catecholamines and serotonin precursor amino acids tyrosine and tryptophan, might be one explanation for the dysfunctional neurotransmission implicated in the pathophysiology of bipolar disorder and Attention Deficit/Hyperactivity Disorder (ADHD). In previous studies, an altered amino acid transport has been found in schizophrenia and autism, when using the fibroblast cell model. LÄS MER

5. 4. Targeting double-stranded DNA with locked nucleic acid-based (LNA) oligonucleotides (ON) and DNA-binding peptide conjugates

   Författare :Y Vladimir Pabón-Martínez; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In this thesis we have studied two different types of molecules that bind to the major groove of the DNA: (i) oligonucleotides (ONs) containing locked nucleic acid (LNA) and in combination with intercalating agents (Twisted Intercalating Nucleic Acid, TINA, and Benzoquinoquinoxaline, BQQ) and (ii) peptides mimicking the leucine zipper transcription factor (GCN4 bZIP TF). Both ONs and peptides bind to the DNA double helix aiming to serve as transcription regulators of disease related genes. LÄS MER

7. 5. The effect of sequence truncation and amino-acid substitutions on the biophysical properties of protein S and calbindin D9k

   Författare :Karin Julenius; Biofysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; surface plasmon resonance; fluorescence spectroscopy; circular dichroism spectroscopy; NMR spectroscopy; hydrophobic effect; protein stability; dimerization; cooperativity; calcium binding; EGF-module; EF-hand; calbindin D9k; protein S; synthet; Physical chemistry; Fysikalisk kemi;

   Sammanfattning : Protein S is a modular protein and a cofactor in the protein C anticoagulant system. It consists of a Gla-module, a thrombin-sensitive loop, four EGF-modules and a SHBG-like module. LÄS MER